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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PPP2R3A
All Species:
13.03
Human Site:
S274
Identified Species:
23.89
UniProt:
Q06190
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q06190
NP_002709.2
1150
130278
S274
G
N
D
T
I
S
S
S
E
T
V
Y
M
N
V
Chimpanzee
Pan troglodytes
XP_001153482
1150
130149
S274
G
N
D
T
I
S
S
S
E
T
V
Y
M
N
V
Rhesus Macaque
Macaca mulatta
XP_001115107
1150
130076
S274
G
N
D
T
F
S
S
S
E
T
V
Y
M
N
V
Dog
Lupus familis
XP_542792
1152
130075
S274
G
N
D
A
I
S
S
S
D
T
V
Y
V
N
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z176
491
55687
Rat
Rattus norvegicus
NP_001012202
1150
129888
E274
S
D
A
M
S
N
S
E
T
V
Y
M
N
V
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518335
657
71327
Chicken
Gallus gallus
XP_422556
1117
125703
I274
P
L
A
S
S
E
M
I
Y
M
N
L
M
R
R
Frog
Xenopus laevis
NP_001082623
1127
126700
P275
G
K
G
E
D
H
F
P
N
P
E
I
I
Y
M
Zebra Danio
Brachydanio rerio
XP_694203
1163
130076
K280
G
N
P
E
I
I
Y
K
N
V
M
A
R
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650842
888
97842
K54
A
G
S
G
V
S
S
K
V
S
K
A
Q
G
A
Honey Bee
Apis mellifera
XP_396366
1240
138144
K314
F
A
L
E
K
F
E
K
N
S
M
Q
Q
Q
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784322
739
85352
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.6
90.4
N.A.
27.8
85
N.A.
34
59.6
54
55.5
N.A.
32.6
30.7
N.A.
31.1
Protein Similarity:
100
99.7
98.8
94.6
N.A.
34.5
91
N.A.
43.1
73.3
68.7
70.8
N.A.
47.7
47.1
N.A.
45
P-Site Identity:
100
100
93.3
80
N.A.
0
6.6
N.A.
0
6.6
6.6
20
N.A.
13.3
0
N.A.
0
P-Site Similarity:
100
100
93.3
93.3
N.A.
0
26.6
N.A.
0
13.3
20
26.6
N.A.
26.6
13.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
16
8
0
0
0
0
0
0
0
16
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
31
0
8
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
0
24
0
8
8
8
24
0
8
0
0
0
0
% E
% Phe:
8
0
0
0
8
8
8
0
0
0
0
0
0
0
0
% F
% Gly:
47
8
8
8
0
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
31
8
0
8
0
0
0
8
8
0
0
% I
% Lys:
0
8
0
0
8
0
0
24
0
0
8
0
0
0
0
% K
% Leu:
0
8
8
0
0
0
0
0
0
0
0
8
0
8
0
% L
% Met:
0
0
0
8
0
0
8
0
0
8
16
8
31
0
16
% M
% Asn:
0
39
0
0
0
8
0
0
24
0
8
0
8
31
0
% N
% Pro:
8
0
8
0
0
0
0
8
0
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
16
8
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
8
% R
% Ser:
8
0
8
8
16
39
47
31
0
16
0
0
0
0
8
% S
% Thr:
0
0
0
24
0
0
0
0
8
31
0
0
0
0
0
% T
% Val:
0
0
0
0
8
0
0
0
8
16
31
0
8
8
31
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
8
0
8
31
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _