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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE3A All Species: 23.94
Human Site: T244 Identified Species: 40.51
UniProt: Q05086 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05086 NP_000453.2 875 100688 T244 D A I R R V Y T R L L S N E K
Chimpanzee Pan troglodytes XP_510256 879 101065 T248 D A I R R V Y T R L L S N E K
Rhesus Macaque Macaca mulatta XP_001108510 879 101081 T248 D A I R R V Y T R L L S N E K
Dog Lupus familis XP_848240 875 100388 T244 E A I R R V Y T R L L S N E K
Cat Felis silvestris
Mouse Mus musculus O08759 885 101157 S255 D A I R R V Y S S L L A N E K
Rat Rattus norvegicus Q5PQN1 1057 118521 T401 D P S K Q I W T V N E A L I Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514205 825 94298 H238 R M N R K E A H G P R D D F K
Chicken Gallus gallus XP_416882 880 100974 D249 E A V R R V Y D R L L S N E K
Frog Xenopus laevis Q6DCL5 944 106566 C328 L R I V R I F C H V F R I G P
Zebra Danio Brachydanio rerio NP_001007319 857 97523 A241 I E A A F L N A L V Y L S P N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9Y0H4 949 107948 P301 P A P A L A R P L T Q V Y G A
Honey Bee Apis mellifera XP_394656 898 100748 S280 R A F A A L W S L P G E V F K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203179 881 99830 I250 V Q R V Y E A I T K L D E E R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40985 892 103438 T257 L N I P T I R T C L I R D R K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 98.5 97.5 N.A. 92.8 26 N.A. 66.9 93.5 22.5 84.5 N.A. 23.6 48.3 N.A. 51.3
Protein Similarity: 100 99 98.9 98.4 N.A. 95.2 43.7 N.A. 73.4 96.5 40.7 90.9 N.A. 41.2 66.5 N.A. 69.2
P-Site Identity: 100 100 100 93.3 N.A. 80 13.3 N.A. 13.3 80 13.3 0 N.A. 6.6 13.3 N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 93.3 53.3 N.A. 26.6 93.3 33.3 20 N.A. 6.6 33.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 58 8 22 8 8 15 8 0 0 0 15 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % C
% Asp: 36 0 0 0 0 0 0 8 0 0 0 15 15 0 0 % D
% Glu: 15 8 0 0 0 15 0 0 0 0 8 8 8 50 0 % E
% Phe: 0 0 8 0 8 0 8 0 0 0 8 0 0 15 0 % F
% Gly: 0 0 0 0 0 0 0 0 8 0 8 0 0 15 0 % G
% His: 0 0 0 0 0 0 0 8 8 0 0 0 0 0 0 % H
% Ile: 8 0 50 0 0 22 0 8 0 0 8 0 8 8 0 % I
% Lys: 0 0 0 8 8 0 0 0 0 8 0 0 0 0 65 % K
% Leu: 15 0 0 0 8 15 0 0 22 50 50 8 8 0 0 % L
% Met: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 0 0 8 0 0 8 0 0 43 0 8 % N
% Pro: 8 8 8 8 0 0 0 8 0 15 0 0 0 8 8 % P
% Gln: 0 8 0 0 8 0 0 0 0 0 8 0 0 0 8 % Q
% Arg: 15 8 8 50 50 0 15 0 36 0 8 15 0 8 8 % R
% Ser: 0 0 8 0 0 0 0 15 8 0 0 36 8 0 0 % S
% Thr: 0 0 0 0 8 0 0 43 8 8 0 0 0 0 0 % T
% Val: 8 0 8 15 0 43 0 0 8 15 0 8 8 0 0 % V
% Trp: 0 0 0 0 0 0 15 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 8 0 43 0 0 0 8 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _