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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE3A All Species: 34.55
Human Site: S744 Identified Species: 58.46
UniProt: Q05086 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05086 NP_000453.2 875 100688 S744 F H M V T N E S P L K Y L F R
Chimpanzee Pan troglodytes XP_510256 879 101065 S748 F H M V T N E S P L K Y L F R
Rhesus Macaque Macaca mulatta XP_001108510 879 101081 S748 F H M V T N E S P L K Y L F R
Dog Lupus familis XP_848240 875 100388 S744 F H M V T N E S P L K Y L F R
Cat Felis silvestris
Mouse Mus musculus O08759 885 101157 S754 F H M V T N E S P L K Y L F R
Rat Rattus norvegicus Q5PQN1 1057 118521 G926 G F H K V C G G K V L L L F Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514205 825 94298 E695 D E G G V S K E F F Q L V V E
Chicken Gallus gallus XP_416882 880 100974 S749 F H M V T N E S P L K Y L F R
Frog Xenopus laevis Q6DCL5 944 106566 P805 G F H M F I P P S L I Q L F D
Zebra Danio Brachydanio rerio NP_001007319 857 97523 S726 F H M V T N E S P L K Y L F R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9Y0H4 949 107948 L813 G F N E V V P L E W L K Y F D
Honey Bee Apis mellifera XP_394656 898 100748 S767 F Q M V T D E S P L A L L F R
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203179 881 99830 S750 F D M V T D E S P L R N W F R
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40985 892 103438 I760 V F A E C N S I K L F N S E E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 98.5 97.5 N.A. 92.8 26 N.A. 66.9 93.5 22.5 84.5 N.A. 23.6 48.3 N.A. 51.3
Protein Similarity: 100 99 98.9 98.4 N.A. 95.2 43.7 N.A. 73.4 96.5 40.7 90.9 N.A. 41.2 66.5 N.A. 69.2
P-Site Identity: 100 100 100 100 N.A. 100 13.3 N.A. 0 100 20 100 N.A. 6.6 73.3 N.A. 66.6
P-Site Similarity: 100 100 100 100 N.A. 100 26.6 N.A. 26.6 100 26.6 100 N.A. 6.6 80 N.A. 80
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 0 0 0 8 0 0 0 0 % A
% Cys: 0 0 0 0 8 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 8 0 0 0 15 0 0 0 0 0 0 0 0 15 % D
% Glu: 0 8 0 15 0 0 65 8 8 0 0 0 0 8 15 % E
% Phe: 65 29 0 0 8 0 0 0 8 8 8 0 0 86 0 % F
% Gly: 22 0 8 8 0 0 8 8 0 0 0 0 0 0 0 % G
% His: 0 50 15 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 0 8 0 0 8 0 0 0 0 % I
% Lys: 0 0 0 8 0 0 8 0 15 0 50 8 0 0 0 % K
% Leu: 0 0 0 0 0 0 0 8 0 79 15 22 72 0 0 % L
% Met: 0 0 65 8 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 58 0 0 0 0 0 15 0 0 0 % N
% Pro: 0 0 0 0 0 0 15 8 65 0 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 0 0 0 0 0 8 8 0 0 8 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 65 % R
% Ser: 0 0 0 0 0 8 8 65 8 0 0 0 8 0 0 % S
% Thr: 0 0 0 0 65 0 0 0 0 0 0 0 0 0 0 % T
% Val: 8 0 0 65 22 8 0 0 0 8 0 0 8 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 50 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _