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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE3A All Species: 17.88
Human Site: S248 Identified Species: 30.26
UniProt: Q05086 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05086 NP_000453.2 875 100688 S248 R V Y T R L L S N E K I E T A
Chimpanzee Pan troglodytes XP_510256 879 101065 S252 R V Y T R L L S N E K I E T A
Rhesus Macaque Macaca mulatta XP_001108510 879 101081 S252 R V Y T R L L S N E K I E T A
Dog Lupus familis XP_848240 875 100388 S248 R V Y T R L L S N E K I E T A
Cat Felis silvestris
Mouse Mus musculus O08759 885 101157 A259 R V Y S S L L A N E K L E T A
Rat Rattus norvegicus Q5PQN1 1057 118521 A405 Q I W T V N E A L I Q K W L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514205 825 94298 D242 K E A H G P R D D F K D V T Y
Chicken Gallus gallus XP_416882 880 100974 S253 R V Y D R L L S N E K I E T A
Frog Xenopus laevis Q6DCL5 944 106566 R332 R I F C H V F R I G P S S P N
Zebra Danio Brachydanio rerio NP_001007319 857 97523 L245 F L N A L V Y L S P N V E C D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9Y0H4 949 107948 V305 L A R P L T Q V Y G A L P E N
Honey Bee Apis mellifera XP_394656 898 100748 E284 A L W S L P G E V F K S A L V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203179 881 99830 D254 Y E A I T K L D E E R V N N A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40985 892 103438 R261 T I R T C L I R D R K S K N V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 98.5 97.5 N.A. 92.8 26 N.A. 66.9 93.5 22.5 84.5 N.A. 23.6 48.3 N.A. 51.3
Protein Similarity: 100 99 98.9 98.4 N.A. 95.2 43.7 N.A. 73.4 96.5 40.7 90.9 N.A. 41.2 66.5 N.A. 69.2
P-Site Identity: 100 100 100 100 N.A. 73.3 6.6 N.A. 13.3 93.3 6.6 6.6 N.A. 0 6.6 N.A. 20
P-Site Similarity: 100 100 100 100 N.A. 93.3 46.6 N.A. 26.6 93.3 26.6 33.3 N.A. 6.6 26.6 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 8 15 8 0 0 0 15 0 0 8 0 8 0 50 % A
% Cys: 0 0 0 8 8 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 8 0 0 0 15 15 0 0 8 0 0 8 % D
% Glu: 0 15 0 0 0 0 8 8 8 50 0 0 50 8 0 % E
% Phe: 8 0 8 0 0 0 8 0 0 15 0 0 0 0 0 % F
% Gly: 0 0 0 0 8 0 8 0 0 15 0 0 0 0 0 % G
% His: 0 0 0 8 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 22 0 8 0 0 8 0 8 8 0 36 0 0 0 % I
% Lys: 8 0 0 0 0 8 0 0 0 0 65 8 8 0 0 % K
% Leu: 8 15 0 0 22 50 50 8 8 0 0 15 0 15 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 8 0 0 43 0 8 0 8 15 15 % N
% Pro: 0 0 0 8 0 15 0 0 0 8 8 0 8 8 0 % P
% Gln: 8 0 0 0 0 0 8 0 0 0 8 0 0 0 0 % Q
% Arg: 50 0 15 0 36 0 8 15 0 8 8 0 0 0 0 % R
% Ser: 0 0 0 15 8 0 0 36 8 0 0 22 8 0 8 % S
% Thr: 8 0 0 43 8 8 0 0 0 0 0 0 0 50 0 % T
% Val: 0 43 0 0 8 15 0 8 8 0 0 15 8 0 15 % V
% Trp: 0 0 15 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 8 0 43 0 0 0 8 0 8 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _