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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
UBE3A
All Species:
26.36
Human Site:
S218
Identified Species:
44.62
UniProt:
Q05086
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05086
NP_000453.2
875
100688
S218
S
S
R
I
G
D
S
S
Q
G
D
N
N
L
Q
Chimpanzee
Pan troglodytes
XP_510256
879
101065
S222
S
S
R
I
G
D
S
S
Q
G
D
N
N
L
Q
Rhesus Macaque
Macaca mulatta
XP_001108510
879
101081
S222
S
S
R
I
G
D
S
S
Q
G
D
N
N
L
Q
Dog
Lupus familis
XP_848240
875
100388
S218
S
S
R
I
S
D
S
S
Q
G
D
N
N
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
O08759
885
101157
S229
S
S
R
M
G
D
S
S
Q
G
D
N
N
V
Q
Rat
Rattus norvegicus
Q5PQN1
1057
118521
F375
F
S
G
G
D
Q
S
F
S
H
Y
S
S
P
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514205
825
94298
S212
P
S
K
K
G
A
S
S
A
Y
L
E
T
N
S
Chicken
Gallus gallus
XP_416882
880
100974
T223
S
S
R
I
G
E
N
T
Q
G
D
N
N
L
Q
Frog
Xenopus laevis
Q6DCL5
944
106566
N302
L
A
E
V
A
T
T
N
G
H
K
L
L
S
I
Zebra Danio
Brachydanio rerio
NP_001007319
857
97523
S215
K
L
G
P
V
E
V
S
V
D
I
D
A
V
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y0H4
949
107948
M275
N
Q
Q
Q
P
L
R
M
V
N
G
S
G
A
A
Honey Bee
Apis mellifera
XP_394656
898
100748
P254
K
E
E
D
S
S
E
P
S
P
T
V
P
N
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001203179
881
99830
D224
S
T
R
L
A
D
H
D
L
G
E
C
S
S
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40985
892
103438
T231
N
D
L
L
K
R
I
T
I
N
K
G
E
N
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
98.5
97.5
N.A.
92.8
26
N.A.
66.9
93.5
22.5
84.5
N.A.
23.6
48.3
N.A.
51.3
Protein Similarity:
100
99
98.9
98.4
N.A.
95.2
43.7
N.A.
73.4
96.5
40.7
90.9
N.A.
41.2
66.5
N.A.
69.2
P-Site Identity:
100
100
100
93.3
N.A.
86.6
20
N.A.
26.6
80
0
6.6
N.A.
0
0
N.A.
26.6
P-Site Similarity:
100
100
100
93.3
N.A.
100
33.3
N.A.
33.3
100
26.6
33.3
N.A.
20
0
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
15
8
0
0
8
0
0
0
8
8
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
8
0
8
8
43
0
8
0
8
43
8
0
0
0
% D
% Glu:
0
8
15
0
0
15
8
0
0
0
8
8
8
0
0
% E
% Phe:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
15
8
43
0
0
0
8
50
8
8
8
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
15
0
0
0
0
0
% H
% Ile:
0
0
0
36
0
0
8
0
8
0
8
0
0
0
8
% I
% Lys:
15
0
8
8
8
0
0
0
0
0
15
0
0
0
8
% K
% Leu:
8
8
8
15
0
8
0
0
8
0
8
8
8
36
8
% L
% Met:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
15
0
0
0
0
0
8
8
0
15
0
43
43
22
8
% N
% Pro:
8
0
0
8
8
0
0
8
0
8
0
0
8
8
0
% P
% Gln:
0
8
8
8
0
8
0
0
43
0
0
0
0
0
50
% Q
% Arg:
0
0
50
0
0
8
8
0
0
0
0
0
0
0
8
% R
% Ser:
50
58
0
0
15
8
50
50
15
0
0
15
15
15
8
% S
% Thr:
0
8
0
0
0
8
8
15
0
0
8
0
8
0
0
% T
% Val:
0
0
0
8
8
0
8
0
15
0
0
8
0
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _