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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE3A All Species: 26.36
Human Site: S218 Identified Species: 44.62
UniProt: Q05086 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05086 NP_000453.2 875 100688 S218 S S R I G D S S Q G D N N L Q
Chimpanzee Pan troglodytes XP_510256 879 101065 S222 S S R I G D S S Q G D N N L Q
Rhesus Macaque Macaca mulatta XP_001108510 879 101081 S222 S S R I G D S S Q G D N N L Q
Dog Lupus familis XP_848240 875 100388 S218 S S R I S D S S Q G D N N L Q
Cat Felis silvestris
Mouse Mus musculus O08759 885 101157 S229 S S R M G D S S Q G D N N V Q
Rat Rattus norvegicus Q5PQN1 1057 118521 F375 F S G G D Q S F S H Y S S P Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514205 825 94298 S212 P S K K G A S S A Y L E T N S
Chicken Gallus gallus XP_416882 880 100974 T223 S S R I G E N T Q G D N N L Q
Frog Xenopus laevis Q6DCL5 944 106566 N302 L A E V A T T N G H K L L S I
Zebra Danio Brachydanio rerio NP_001007319 857 97523 S215 K L G P V E V S V D I D A V R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9Y0H4 949 107948 M275 N Q Q Q P L R M V N G S G A A
Honey Bee Apis mellifera XP_394656 898 100748 P254 K E E D S S E P S P T V P N N
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203179 881 99830 D224 S T R L A D H D L G E C S S K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40985 892 103438 T231 N D L L K R I T I N K G E N L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 98.5 97.5 N.A. 92.8 26 N.A. 66.9 93.5 22.5 84.5 N.A. 23.6 48.3 N.A. 51.3
Protein Similarity: 100 99 98.9 98.4 N.A. 95.2 43.7 N.A. 73.4 96.5 40.7 90.9 N.A. 41.2 66.5 N.A. 69.2
P-Site Identity: 100 100 100 93.3 N.A. 86.6 20 N.A. 26.6 80 0 6.6 N.A. 0 0 N.A. 26.6
P-Site Similarity: 100 100 100 93.3 N.A. 100 33.3 N.A. 33.3 100 26.6 33.3 N.A. 20 0 N.A. 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 15 8 0 0 8 0 0 0 8 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 8 0 8 8 43 0 8 0 8 43 8 0 0 0 % D
% Glu: 0 8 15 0 0 15 8 0 0 0 8 8 8 0 0 % E
% Phe: 8 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % F
% Gly: 0 0 15 8 43 0 0 0 8 50 8 8 8 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 15 0 0 0 0 0 % H
% Ile: 0 0 0 36 0 0 8 0 8 0 8 0 0 0 8 % I
% Lys: 15 0 8 8 8 0 0 0 0 0 15 0 0 0 8 % K
% Leu: 8 8 8 15 0 8 0 0 8 0 8 8 8 36 8 % L
% Met: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % M
% Asn: 15 0 0 0 0 0 8 8 0 15 0 43 43 22 8 % N
% Pro: 8 0 0 8 8 0 0 8 0 8 0 0 8 8 0 % P
% Gln: 0 8 8 8 0 8 0 0 43 0 0 0 0 0 50 % Q
% Arg: 0 0 50 0 0 8 8 0 0 0 0 0 0 0 8 % R
% Ser: 50 58 0 0 15 8 50 50 15 0 0 15 15 15 8 % S
% Thr: 0 8 0 0 0 8 8 15 0 0 8 0 8 0 0 % T
% Val: 0 0 0 8 8 0 8 0 15 0 0 8 0 15 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _