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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: UBE3A All Species: 25.76
Human Site: S180 Identified Species: 43.59
UniProt: Q05086 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q05086 NP_000453.2 875 100688 S180 H T K E E L K S L Q A K D E D
Chimpanzee Pan troglodytes XP_510256 879 101065 S184 H T K E E L K S L Q A K D E D
Rhesus Macaque Macaca mulatta XP_001108510 879 101081 S184 H T K E E L K S L Q A K D E D
Dog Lupus familis XP_848240 875 100388 S181 H T K E E L K S L Q G K D E D
Cat Felis silvestris
Mouse Mus musculus O08759 885 101157 S191 H T K D E L K S L Q E K D E D
Rat Rattus norvegicus Q5PQN1 1057 118521 S186 T S P Q L I K S L L G I P F M
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514205 825 94298 F178 F C A S C P T F L R L D N N A
Chicken Gallus gallus XP_416882 880 100974 S182 H T K E E L K S L Q G K D E D
Frog Xenopus laevis Q6DCL5 944 106566 N265 T L I Q M T Q N E E L R E N M
Zebra Danio Brachydanio rerio NP_001007319 857 97523 E176 D K D E D E K E T A S G S S T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9Y0H4 949 107948 R227 V R A R M R L R S S S G N S N
Honey Bee Apis mellifera XP_394656 898 100748 L219 N D S P L A A L L D R A S D S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203179 881 99830 T188 L N K S F L R T V K Q G L S D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40985 892 103438 N196 G K N I K M L N Y E V L Q R F
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.7 98.5 97.5 N.A. 92.8 26 N.A. 66.9 93.5 22.5 84.5 N.A. 23.6 48.3 N.A. 51.3
Protein Similarity: 100 99 98.9 98.4 N.A. 95.2 43.7 N.A. 73.4 96.5 40.7 90.9 N.A. 41.2 66.5 N.A. 69.2
P-Site Identity: 100 100 100 93.3 N.A. 86.6 20 N.A. 6.6 93.3 0 13.3 N.A. 0 6.6 N.A. 20
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 40 N.A. 20 93.3 40 26.6 N.A. 20 20 N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 24.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 46.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 0 0 8 8 0 0 8 22 8 0 0 8 % A
% Cys: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 8 8 8 8 0 0 0 0 8 0 8 43 8 50 % D
% Glu: 0 0 0 43 43 8 0 8 8 15 8 0 8 43 0 % E
% Phe: 8 0 0 0 8 0 0 8 0 0 0 0 0 8 8 % F
% Gly: 8 0 0 0 0 0 0 0 0 0 22 22 0 0 0 % G
% His: 43 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 8 8 0 8 0 0 0 0 0 8 0 0 0 % I
% Lys: 0 15 50 0 8 0 58 0 0 8 0 43 0 0 0 % K
% Leu: 8 8 0 0 15 50 15 8 65 8 15 8 8 0 0 % L
% Met: 0 0 0 0 15 8 0 0 0 0 0 0 0 0 15 % M
% Asn: 8 8 8 0 0 0 0 15 0 0 0 0 15 15 8 % N
% Pro: 0 0 8 8 0 8 0 0 0 0 0 0 8 0 0 % P
% Gln: 0 0 0 15 0 0 8 0 0 43 8 0 8 0 0 % Q
% Arg: 0 8 0 8 0 8 8 8 0 8 8 8 0 8 0 % R
% Ser: 0 8 8 15 0 0 0 50 8 8 15 0 15 22 8 % S
% Thr: 15 43 0 0 0 8 8 8 8 0 0 0 0 0 8 % T
% Val: 8 0 0 0 0 0 0 0 8 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _