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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLE3
All Species:
20.61
Human Site:
Y220
Identified Species:
41.21
UniProt:
Q04726
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04726
NP_001098662.1
772
83417
Y220
K
H
R
G
S
A
D
Y
S
M
E
A
K
K
R
Chimpanzee
Pan troglodytes
XP_523111
764
82577
Y220
K
H
R
G
S
A
D
Y
S
M
E
A
K
K
R
Rhesus Macaque
Macaca mulatta
XP_001086565
749
80505
R212
Y
S
M
E
A
K
K
R
K
A
E
E
K
D
S
Dog
Lupus familis
XP_544749
711
76447
E175
A
K
K
R
K
A
E
E
K
D
S
L
S
R
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q08122
772
83428
Y220
K
H
R
G
S
A
D
Y
S
M
E
A
K
K
R
Rat
Rattus norvegicus
Q9JIT3
764
82625
Y220
K
H
R
G
S
A
D
Y
S
M
E
A
K
K
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511916
767
82978
S220
H
R
N
S
T
D
Y
S
S
D
S
K
K
Q
K
Chicken
Gallus gallus
Frog
Xenopus laevis
O42478
772
83688
S227
H
R
N
S
T
D
Y
S
S
E
S
K
K
Q
K
Zebra Danio
Brachydanio rerio
O13166
761
82441
K219
S
L
R
T
T
S
E
K
H
R
G
S
S
D
Y
Tiger Blowfish
Takifugu rubipres
NP_001032949
763
82638
Y221
K
H
R
G
S
S
D
Y
N
H
D
P
K
K
R
Fruit Fly
Dros. melanogaster
P16371
730
80213
G194
I
K
P
T
G
L
E
G
P
A
A
A
E
E
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O02482
612
65598
L76
Q
E
F
I
M
Q
S
L
A
P
Q
L
S
Q
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.8
94.3
91.7
N.A.
98.9
98.1
N.A.
83
N.A.
82.6
87.6
91.4
61.1
N.A.
39.9
N.A.
Protein Similarity:
100
98.8
94.6
91.7
N.A.
99.2
98.3
N.A.
89.9
N.A.
89.5
90.6
94.1
72.1
N.A.
53.8
N.A.
P-Site Identity:
100
100
13.3
6.6
N.A.
100
100
N.A.
13.3
N.A.
13.3
6.6
66.6
13.3
N.A.
0
N.A.
P-Site Similarity:
100
100
20
26.6
N.A.
100
100
N.A.
33.3
N.A.
33.3
33.3
86.6
33.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
9
42
0
0
9
17
9
42
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
17
42
0
0
17
9
0
0
17
9
% D
% Glu:
0
9
0
9
0
0
25
9
0
9
42
9
9
9
0
% E
% Phe:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
42
9
0
0
9
0
0
9
0
0
0
0
% G
% His:
17
42
0
0
0
0
0
0
9
9
0
0
0
0
0
% H
% Ile:
9
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
42
17
9
0
9
9
9
9
17
0
0
17
67
42
17
% K
% Leu:
0
9
0
0
0
9
0
9
0
0
0
17
0
0
0
% L
% Met:
0
0
9
0
9
0
0
0
0
34
0
0
0
0
0
% M
% Asn:
0
0
17
0
0
0
0
0
9
0
0
0
0
0
0
% N
% Pro:
0
0
9
0
0
0
0
0
9
9
0
9
0
0
0
% P
% Gln:
9
0
0
0
0
9
0
0
0
0
9
0
0
25
0
% Q
% Arg:
0
17
50
9
0
0
0
9
0
9
0
0
0
9
50
% R
% Ser:
9
9
0
17
42
17
9
17
50
0
25
9
25
0
9
% S
% Thr:
0
0
0
17
25
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
0
0
17
42
0
0
0
0
0
0
17
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _