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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TLE3 All Species: 36.36
Human Site: S622 Identified Species: 72.73
UniProt: Q04726 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q04726 NP_001098662.1 772 83417 S622 Q G H T D G A S C I D I S H D
Chimpanzee Pan troglodytes XP_523111 764 82577 S614 Q G H T D G A S C I D I S H D
Rhesus Macaque Macaca mulatta XP_001086565 749 80505 S599 Q G H T D G A S C I D I S H D
Dog Lupus familis XP_544749 711 76447 C562 G H T D G A S C I D I S H D G
Cat Felis silvestris
Mouse Mus musculus Q08122 772 83428 S622 Q G H T D G A S C I D I S H D
Rat Rattus norvegicus Q9JIT3 764 82625 S614 Q G H T D G A S C I D I S H D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511916 767 82978 S617 Q G H T D G A S C I D I S N D
Chicken Gallus gallus
Frog Xenopus laevis O42478 772 83688 S622 Q G H T D G A S C I D I S N D
Zebra Danio Brachydanio rerio O13166 761 82441 S611 Q G H T D G A S C I D I S H D
Tiger Blowfish Takifugu rubipres NP_001032949 763 82638 S613 Q G H T D G A S C I D I S H D
Fruit Fly Dros. melanogaster P16371 730 80213 C581 G H T D G A S C I D I S P D G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans O02482 612 65598 C463 G H Q D G A S C L D L S K D G
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 94.3 91.7 N.A. 98.9 98.1 N.A. 83 N.A. 82.6 87.6 91.4 61.1 N.A. 39.9 N.A.
Protein Similarity: 100 98.8 94.6 91.7 N.A. 99.2 98.3 N.A. 89.9 N.A. 89.5 90.6 94.1 72.1 N.A. 53.8 N.A.
P-Site Identity: 100 100 100 0 N.A. 100 100 N.A. 93.3 N.A. 93.3 100 100 0 N.A. 0 N.A.
P-Site Similarity: 100 100 100 6.6 N.A. 100 100 N.A. 100 N.A. 100 100 100 6.6 N.A. 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 25 75 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 25 75 0 0 0 0 0 0 % C
% Asp: 0 0 0 25 75 0 0 0 0 25 75 0 0 25 75 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 25 75 0 0 25 75 0 0 0 0 0 0 0 0 25 % G
% His: 0 25 75 0 0 0 0 0 0 0 0 0 9 59 0 % H
% Ile: 0 0 0 0 0 0 0 0 17 75 17 75 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 9 0 9 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 17 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % P
% Gln: 75 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 25 75 0 0 0 25 75 0 0 % S
% Thr: 0 0 17 75 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _