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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLE2
All Species:
36.06
Human Site:
T114
Identified Species:
72.12
UniProt:
Q04725
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04725
NP_001138233.1
743
79841
T114
V
E
R
A
K
Q
V
T
V
G
E
L
N
S
L
Chimpanzee
Pan troglodytes
XP_512979
739
79294
T113
V
E
R
A
K
Q
V
T
V
G
E
L
N
S
L
Rhesus Macaque
Macaca mulatta
XP_001102218
778
84646
T121
V
E
R
A
K
Q
V
T
M
A
E
L
N
A
I
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVB2
767
82604
V138
D
R
A
K
Q
V
T
V
G
E
L
N
S
L
L
Rat
Rattus norvegicus
Q9JIT3
764
82625
T115
V
E
R
A
K
Q
V
T
M
T
E
L
N
A
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511916
767
82978
T114
V
E
R
A
K
Q
V
T
M
A
E
L
N
A
I
Chicken
Gallus gallus
NP_989568
773
83801
T121
V
E
R
A
K
Q
V
T
M
A
E
L
N
A
I
Frog
Xenopus laevis
O42478
772
83688
T122
V
E
R
A
K
Q
V
T
M
A
E
L
N
A
I
Zebra Danio
Brachydanio rerio
O13166
761
82441
T115
V
E
R
A
K
Q
V
T
M
T
E
L
N
A
I
Tiger Blowfish
Takifugu rubipres
NP_001032949
763
82638
T115
V
E
R
A
K
Q
V
T
M
T
E
L
N
A
I
Fruit Fly
Dros. melanogaster
P16371
730
80213
K114
L
Q
A
V
E
R
A
K
Q
V
T
M
Q
E
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O02482
612
65598
T8
M
K
A
S
Y
L
E
T
L
D
R
I
K
D
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.9
66.1
N.A.
N.A.
88.7
67.9
N.A.
68.1
67.2
67
64.1
67.1
55
N.A.
38.6
N.A.
Protein Similarity:
100
97.3
78.2
N.A.
N.A.
92.6
79.3
N.A.
79.2
78.5
78.6
75.3
78.7
66.6
N.A.
53.4
N.A.
P-Site Identity:
100
100
73.3
N.A.
N.A.
6.6
73.3
N.A.
73.3
73.3
73.3
73.3
73.3
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
93.3
N.A.
N.A.
20
93.3
N.A.
93.3
93.3
93.3
93.3
93.3
40
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
25
75
0
0
9
0
0
34
0
0
0
59
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
0
9
0
0
0
9
0
% D
% Glu:
0
75
0
0
9
0
9
0
0
9
75
0
0
9
9
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
9
17
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
59
% I
% Lys:
0
9
0
9
75
0
0
9
0
0
0
0
9
0
0
% K
% Leu:
9
0
0
0
0
9
0
0
9
0
9
75
0
9
34
% L
% Met:
9
0
0
0
0
0
0
0
59
0
0
9
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
9
75
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
0
0
9
75
0
0
9
0
0
0
9
0
0
% Q
% Arg:
0
9
75
0
0
9
0
0
0
0
9
0
0
0
0
% R
% Ser:
0
0
0
9
0
0
0
0
0
0
0
0
9
17
0
% S
% Thr:
0
0
0
0
0
0
9
84
0
25
9
0
0
0
0
% T
% Val:
75
0
0
9
0
9
75
9
17
9
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _