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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLE2
All Species:
33.94
Human Site:
S233
Identified Species:
67.88
UniProt:
Q04725
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04725
NP_001138233.1
743
79841
S233
Y
E
S
D
E
D
K
S
D
Y
N
L
V
V
D
Chimpanzee
Pan troglodytes
XP_512979
739
79294
S232
Y
E
S
D
E
D
K
S
D
Y
N
L
V
V
D
Rhesus Macaque
Macaca mulatta
XP_001102218
778
84646
S251
Y
D
S
D
G
E
K
S
D
D
N
L
V
V
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q9WVB2
767
82604
S258
Y
D
S
E
E
D
K
S
D
Y
N
L
V
V
D
Rat
Rattus norvegicus
Q9JIT3
764
82625
S245
Y
D
S
D
G
D
K
S
D
D
L
V
V
D
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511916
767
82978
S244
Y
D
S
D
G
E
K
S
D
D
N
L
V
V
D
Chicken
Gallus gallus
NP_989568
773
83801
S250
Y
D
S
D
G
E
K
S
D
D
N
L
V
V
D
Frog
Xenopus laevis
O42478
772
83688
S251
Y
D
S
D
G
E
K
S
D
D
N
L
V
V
D
Zebra Danio
Brachydanio rerio
O13166
761
82441
S251
Y
D
S
D
G
D
K
S
D
D
L
V
V
D
V
Tiger Blowfish
Takifugu rubipres
NP_001032949
763
82638
S246
Y
D
S
D
G
D
K
S
D
D
L
V
V
D
V
Fruit Fly
Dros. melanogaster
P16371
730
80213
E223
T
R
S
P
L
D
I
E
N
D
S
K
R
R
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O02482
612
65598
P116
A
L
P
P
G
F
P
P
G
A
A
G
M
L
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.9
66.1
N.A.
N.A.
88.7
67.9
N.A.
68.1
67.2
67
64.1
67.1
55
N.A.
38.6
N.A.
Protein Similarity:
100
97.3
78.2
N.A.
N.A.
92.6
79.3
N.A.
79.2
78.5
78.6
75.3
78.7
66.6
N.A.
53.4
N.A.
P-Site Identity:
100
100
73.3
N.A.
N.A.
86.6
53.3
N.A.
73.3
73.3
73.3
53.3
53.3
13.3
N.A.
0
N.A.
P-Site Similarity:
100
100
86.6
N.A.
N.A.
100
66.6
N.A.
86.6
86.6
86.6
66.6
66.6
26.6
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
0
0
0
0
0
9
9
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
67
0
75
0
59
0
0
84
67
0
0
0
25
59
% D
% Glu:
0
17
0
9
25
34
0
9
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
67
0
0
0
9
0
0
9
0
0
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
84
0
0
0
0
9
0
0
9
% K
% Leu:
0
9
0
0
9
0
0
0
0
0
25
59
0
9
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
59
0
0
0
0
% N
% Pro:
0
0
9
17
0
0
9
9
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
9
0
0
0
0
0
0
0
0
0
0
9
9
0
% R
% Ser:
0
0
92
0
0
0
0
84
0
0
9
0
0
0
0
% S
% Thr:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
25
84
59
25
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
84
0
0
0
0
0
0
0
0
25
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _