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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TLE1
All Species:
45.45
Human Site:
Y500
Identified Species:
90.91
UniProt:
Q04724
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04724
NP_005068.2
770
83201
Y500
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Chimpanzee
Pan troglodytes
XP_001150643
778
84474
Y508
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Rhesus Macaque
Macaca mulatta
XP_001104021
768
83055
Y498
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Dog
Lupus familis
XP_533516
891
96769
Y621
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Cat
Felis silvestris
Mouse
Mus musculus
Q62440
770
83078
Y500
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Rat
Rattus norvegicus
Q9JIT3
764
82625
Y494
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511916
767
82978
Y497
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Chicken
Gallus gallus
NP_989568
773
83801
Y503
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Frog
Xenopus laevis
O42478
772
83688
Y502
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Zebra Danio
Brachydanio rerio
O13166
761
82441
Y491
S
N
P
T
R
H
V
Y
T
G
G
K
G
C
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P16371
730
80213
Y460
S
N
P
T
K
Y
V
Y
T
G
G
K
G
C
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O02482
612
65598
G343
R
V
Y
T
G
G
K
G
C
V
K
I
W
D
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
86.3
99.2
85.9
N.A.
97.4
80.7
N.A.
87.6
86.4
85.3
80.3
N.A.
62.3
N.A.
39.7
N.A.
Protein Similarity:
100
91.6
99.3
86.1
N.A.
98.5
88.5
N.A.
92.7
91.7
90.5
85.7
N.A.
70.6
N.A.
54.1
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
86.6
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
100
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
9
0
0
0
0
92
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
9
9
0
9
0
92
92
0
92
0
0
% G
% His:
0
0
0
0
0
84
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% I
% Lys:
0
0
0
0
9
0
9
0
0
0
9
92
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
92
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
92
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
9
0
0
0
84
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
92
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
100
0
0
0
0
92
0
0
0
0
0
0
% T
% Val:
0
9
0
0
0
0
92
0
0
9
0
0
0
0
100
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% W
% Tyr:
0
0
9
0
0
9
0
92
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _