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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
17.68
Human Site:
Y2470
Identified Species:
32.41
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
Y2470
P
H
N
N
M
Q
V
Y
A
_
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
Y2470
P
H
N
N
M
Q
V
Y
A
_
_
_
_
_
_
Dog
Lupus familis
XP_540266
2471
265327
Y2470
P
R
S
N
M
Q
V
Y
A
_
_
_
_
_
_
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
Y2469
P
H
S
N
M
Q
V
Y
A
_
_
_
_
_
_
Rat
Rattus norvegicus
Q9QW30
2471
265351
Y2470
P
H
S
N
M
Q
V
Y
A
_
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
V2465
P
P
R
S
N
T
Q
V
F
A
_
_
_
_
_
Chicken
Gallus gallus
XP_001233596
2467
266140
V2465
Q
Q
R
N
N
M
Q
V
Y
A
_
_
_
_
_
Frog
Xenopus laevis
P21783
2524
275106
M2512
I
S
S
P
P
T
S
M
Q
P
Q
R
T
H
I
Zebra Danio
Brachydanio rerio
P46530
2437
262289
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
N2685
V
Q
S
P
A
A
N
N
L
Y
I
S
G
G
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
Sea Urchin
Strong. purpuratus
P10079
1064
112055
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
0
100
77.7
N.A.
88.8
88.8
N.A.
10
10
0
0
N.A.
0
N.A.
0
0
P-Site Similarity:
100
0
100
88.8
N.A.
100
100
N.A.
20
10
13.3
0
N.A.
33.3
N.A.
0
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
0
39
16
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
8
8
0
% G
% His:
0
31
0
0
0
0
0
0
0
0
0
0
0
8
8
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% L
% Met:
0
0
0
0
39
8
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
16
47
16
0
8
8
0
0
0
0
0
0
0
% N
% Pro:
47
8
0
16
8
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
8
16
0
0
0
39
16
0
8
0
8
0
0
0
0
% Q
% Arg:
0
8
16
0
0
0
0
0
0
0
0
8
0
0
0
% R
% Ser:
0
8
39
8
0
0
8
0
0
0
0
8
0
0
0
% S
% Thr:
0
0
0
0
0
16
0
0
0
0
0
0
8
0
0
% T
% Val:
8
0
0
0
0
0
39
16
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
39
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
39
54
54
54
54
54
% _