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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
37.58
Human Site:
T2012
Identified Species:
68.89
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
T2012
M
Q
D
N
K
E
E
T
P
L
F
L
A
A
R
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
L1738
Y
E
A
A
K
I
L
L
D
H
F
A
N
R
D
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
T2012
M
Q
D
N
K
E
E
T
P
L
F
L
A
A
R
Dog
Lupus familis
XP_540266
2471
265327
T2012
M
Q
D
N
K
E
E
T
P
L
F
L
A
A
R
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
T2010
M
Q
D
N
K
E
E
T
P
L
F
L
A
A
R
Rat
Rattus norvegicus
Q9QW30
2471
265351
T2012
M
Q
D
N
K
E
E
T
P
L
F
L
A
A
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
T2008
M
Q
D
N
K
E
E
T
P
L
F
L
A
A
R
Chicken
Gallus gallus
XP_001233596
2467
266140
T2023
M
Q
D
N
K
E
E
T
P
L
F
L
A
A
R
Frog
Xenopus laevis
P21783
2524
275106
T2060
M
Q
N
N
K
E
E
T
S
L
F
L
A
A
R
Zebra Danio
Brachydanio rerio
P46530
2437
262289
A1994
L
I
L
A
T
R
L
A
V
E
G
M
V
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
T2086
A
Q
D
D
K
D
E
T
P
L
F
L
A
A
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
Y988
Q
R
N
E
L
Q
H
Y
S
L
Y
P
N
P
Q
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G623
F
V
C
T
C
L
P
G
W
E
G
T
N
C
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
13.3
100
100
N.A.
100
100
N.A.
100
100
86.6
0
N.A.
80
N.A.
6.6
0
P-Site Similarity:
100
20
100
100
N.A.
100
100
N.A.
100
100
93.3
13.3
N.A.
93.3
N.A.
40
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
16
0
0
0
8
0
0
0
8
70
70
0
% A
% Cys:
0
0
8
0
8
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
62
8
0
8
0
0
8
0
0
0
0
0
8
% D
% Glu:
0
8
0
8
0
62
70
0
0
16
0
0
0
8
16
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
77
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
16
0
0
0
0
% G
% His:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% H
% Ile:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
77
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
8
0
8
0
8
8
16
8
0
77
0
70
0
0
0
% L
% Met:
62
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
16
62
0
0
0
0
0
0
0
0
24
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
62
0
0
8
0
8
0
% P
% Gln:
8
70
0
0
0
8
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
8
0
0
0
8
0
0
0
0
0
0
0
8
70
% R
% Ser:
0
0
0
0
0
0
0
0
16
0
0
0
0
0
0
% S
% Thr:
0
0
0
8
8
0
0
70
0
0
0
8
0
0
0
% T
% Val:
0
8
0
0
0
0
0
0
8
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _