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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
28.48
Human Site:
S2391
Identified Species:
52.22
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S2391
P
T
P
P
S
Q
H
S
Y
A
S
S
N
A
A
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
Y2100
T
P
P
S
Q
H
S
Y
A
S
S
N
A
A
E
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2391
P
T
P
P
S
Q
H
S
Y
A
S
S
N
A
A
Dog
Lupus familis
XP_540266
2471
265327
S2391
P
T
P
P
S
Q
H
S
Y
A
S
S
N
A
A
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
S2390
P
T
P
P
S
Q
H
S
Y
A
S
S
N
A
A
Rat
Rattus norvegicus
Q9QW30
2471
265351
S2391
P
T
P
P
S
Q
H
S
Y
A
S
S
N
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
S2386
P
T
P
P
S
Q
H
S
Y
A
S
S
T
G
A
Chicken
Gallus gallus
XP_001233596
2467
266140
T2386
S
S
M
G
K
Y
P
T
P
P
S
Q
H
S
C
Frog
Xenopus laevis
P21783
2524
275106
F2433
M
P
Q
D
T
Q
I
F
A
A
S
L
P
S
N
Zebra Danio
Brachydanio rerio
P46530
2437
262289
A2358
P
Q
D
S
Q
R
M
A
P
P
I
S
S
T
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
S2606
P
S
I
Q
S
S
M
S
G
S
S
P
S
T
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
S1350
T
H
L
T
P
P
P
S
D
G
S
T
S
T
P
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G985
A
A
P
T
V
V
V
G
Y
A
S
N
N
Y
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
20
100
100
N.A.
100
100
N.A.
86.6
6.6
20
13.3
N.A.
26.6
N.A.
13.3
33.3
P-Site Similarity:
100
33.3
100
100
N.A.
100
100
N.A.
86.6
33.3
33.3
33.3
N.A.
46.6
N.A.
26.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
0
8
16
62
0
0
8
47
47
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
8
8
0
0
0
0
8
0
0
0
0
0
8
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
8
8
8
0
0
0
8
0
% G
% His:
0
8
0
0
0
8
47
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
8
0
0
0
8
0
0
0
8
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
8
0
0
0
0
0
0
0
0
8
0
0
0
% L
% Met:
8
0
8
0
0
0
16
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
16
47
0
16
% N
% Pro:
62
16
62
47
8
8
16
0
16
16
0
8
8
0
8
% P
% Gln:
0
8
8
8
16
54
0
0
0
0
0
8
0
0
8
% Q
% Arg:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
8
16
0
16
54
8
8
62
0
16
93
54
24
16
0
% S
% Thr:
16
47
0
16
8
0
0
8
0
0
0
8
8
24
0
% T
% Val:
0
0
0
0
8
8
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
8
54
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _