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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
17.58
Human Site:
S2326
Identified Species:
32.22
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S2326
A
G
A
P
Q
P
Q
S
T
C
P
P
A
V
A
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
T2035
G
A
P
Q
P
Q
S
T
C
P
P
A
V
A
G
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2326
A
G
A
P
Q
P
Q
S
T
C
P
P
A
V
T
Dog
Lupus familis
XP_540266
2471
265327
S2326
A
G
T
P
Q
P
Q
S
N
C
P
P
P
V
A
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
S2325
A
G
A
P
Q
T
Q
S
S
C
P
P
A
V
A
Rat
Rattus norvegicus
Q9QW30
2471
265351
S2326
A
G
A
P
Q
T
Q
S
G
C
P
P
A
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
V2321
Q
A
A
G
L
P
Q
V
G
C
P
P
A
M
A
Chicken
Gallus gallus
XP_001233596
2467
266140
L2321
G
G
I
N
Q
Q
A
L
P
Q
Q
A
Q
S
N
Frog
Xenopus laevis
P21783
2524
275106
L2368
R
L
A
N
Q
P
H
L
M
Q
A
Q
Q
M
Q
Zebra Danio
Brachydanio rerio
P46530
2437
262289
V2293
S
A
T
N
M
P
Q
V
M
G
Y
P
T
M
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
Q2541
T
I
S
P
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
N1285
R
Q
L
A
Q
A
N
N
H
H
N
I
V
D
I
Sea Urchin
Strong. purpuratus
P10079
1064
112055
Y920
C
I
D
G
I
A
G
Y
T
C
Q
C
R
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
6.6
93.3
80
N.A.
86.6
86.6
N.A.
53.3
13.3
20
20
N.A.
20
N.A.
6.6
13.3
P-Site Similarity:
100
13.3
93.3
80
N.A.
93.3
86.6
N.A.
60
13.3
26.6
33.3
N.A.
26.6
N.A.
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
39
24
47
8
0
16
8
0
0
0
8
16
39
8
39
% A
% Cys:
8
0
0
0
0
0
0
0
8
54
0
8
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
16
47
0
16
0
0
8
0
16
8
0
0
0
0
16
% G
% His:
0
0
0
0
0
0
8
0
8
8
0
0
0
0
0
% H
% Ile:
0
16
8
0
8
0
0
0
0
0
0
8
0
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
8
0
8
0
0
16
0
0
0
0
0
8
0
% L
% Met:
0
0
0
0
8
0
0
0
16
0
0
0
0
24
0
% M
% Asn:
0
0
0
24
0
0
8
8
8
0
8
0
0
0
8
% N
% Pro:
0
0
8
47
8
47
0
0
8
8
54
54
8
0
0
% P
% Gln:
8
8
0
8
70
24
62
8
8
24
24
16
24
8
24
% Q
% Arg:
16
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
8
0
8
0
0
0
8
39
8
0
0
0
0
8
0
% S
% Thr:
8
0
16
0
0
16
0
8
24
0
0
0
8
0
8
% T
% Val:
0
0
0
0
0
0
0
16
0
0
0
0
16
39
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _