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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
9.39
Human Site:
S2235
Identified Species:
17.22
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S2235
H
H
I
V
S
P
G
S
G
S
A
G
S
L
S
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
L1949
G
S
G
S
A
G
S
L
S
R
L
H
P
V
P
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2235
H
H
I
V
P
P
S
S
G
S
A
G
S
L
S
Dog
Lupus familis
XP_540266
2471
265327
N2235
H
H
I
A
P
P
G
N
G
S
A
G
S
L
G
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
S2233
H
H
I
A
P
P
G
S
S
S
A
G
S
L
G
Rat
Rattus norvegicus
Q9QW30
2471
265351
G2235
H
I
V
P
P
G
S
G
S
A
G
S
L
G
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
G2231
R
L
A
P
P
G
G
G
G
G
S
L
G
R
L
Chicken
Gallus gallus
XP_001233596
2467
266140
T2235
L
L
S
Q
H
R
T
T
P
P
S
S
G
L
G
Frog
Xenopus laevis
P21783
2524
275106
S2280
S
S
P
N
T
I
M
S
N
G
S
M
H
F
T
Zebra Danio
Brachydanio rerio
P46530
2437
262289
Q2206
P
M
M
T
S
P
F
Q
Q
S
P
P
I
S
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
D2300
G
N
L
P
S
P
Y
D
T
S
S
M
Y
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
R1199
V
D
Y
D
G
A
A
R
K
D
S
E
K
Y
K
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G834
A
S
D
P
C
L
N
G
G
I
C
V
D
G
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
0
86.6
73.3
N.A.
73.3
6.6
N.A.
13.3
6.6
6.6
20
N.A.
20
N.A.
0
6.6
P-Site Similarity:
100
13.3
86.6
80
N.A.
73.3
20
N.A.
20
20
26.6
26.6
N.A.
46.6
N.A.
6.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
16
8
8
8
0
0
8
31
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
8
8
8
0
0
0
8
0
8
0
0
8
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% E
% Phe:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% F
% Gly:
16
0
8
0
8
24
31
24
39
16
8
31
16
16
24
% G
% His:
39
31
0
0
8
0
0
0
0
0
0
8
8
0
0
% H
% Ile:
0
8
31
0
0
8
0
0
0
8
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
8
% K
% Leu:
8
16
8
0
0
8
0
8
0
0
8
8
8
39
16
% L
% Met:
0
8
8
0
0
0
8
0
0
0
0
16
0
0
0
% M
% Asn:
0
8
0
8
0
0
8
8
8
0
0
0
0
0
8
% N
% Pro:
8
0
8
31
39
47
0
0
8
8
8
8
8
0
8
% P
% Gln:
0
0
0
8
0
0
0
8
8
0
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
8
0
8
0
8
0
0
0
8
8
% R
% Ser:
8
24
8
8
24
0
24
31
24
47
39
16
31
16
16
% S
% Thr:
0
0
0
8
8
0
8
8
8
0
0
0
0
0
8
% T
% Val:
8
0
8
16
0
0
0
0
0
0
0
8
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
8
0
0
0
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _