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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
25.15
Human Site:
S2162
Identified Species:
46.11
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S2162
E
S
P
H
T
Y
V
S
D
T
T
S
S
P
M
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
P1876
V
S
D
T
T
S
S
P
M
I
T
S
P
G
I
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2162
E
S
P
H
T
Y
V
S
D
T
T
S
S
P
M
Dog
Lupus familis
XP_540266
2471
265327
S2162
E
S
P
H
T
Y
V
S
D
T
T
S
S
P
M
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
S2160
E
S
P
H
T
Y
V
S
D
A
T
S
S
P
M
Rat
Rattus norvegicus
Q9QW30
2471
265351
S2162
E
S
P
H
T
Y
V
S
D
A
T
S
S
P
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
Y2158
S
L
E
S
P
H
A
Y
G
S
D
A
T
P
S
Chicken
Gallus gallus
XP_001233596
2467
266140
L2162
T
L
S
P
V
D
S
L
E
S
P
H
A
F
A
Frog
Xenopus laevis
P21783
2524
275106
S2207
E
S
T
H
G
Y
L
S
D
V
S
S
P
P
L
Zebra Danio
Brachydanio rerio
P46530
2437
262289
N2133
G
I
K
P
S
P
G
N
N
N
N
T
A
K
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
S2227
S
L
R
R
K
A
S
S
K
K
T
S
A
A
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
S1126
D
P
T
I
Y
N
K
S
E
R
S
A
L
H
Q
Sea Urchin
Strong. purpuratus
P10079
1064
112055
C761
P
C
L
N
G
G
A
C
I
E
M
V
N
G
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
26.6
100
100
N.A.
93.3
93.3
N.A.
6.6
0
53.3
0
N.A.
20
N.A.
6.6
0
P-Site Similarity:
100
33.3
100
100
N.A.
93.3
93.3
N.A.
33.3
20
73.3
33.3
N.A.
26.6
N.A.
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
16
0
0
16
0
16
24
8
8
% A
% Cys:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
0
0
8
0
0
47
0
8
0
0
0
0
% D
% Glu:
47
0
8
0
0
0
0
0
16
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
8
0
0
0
16
8
8
0
8
0
0
0
0
16
0
% G
% His:
0
0
0
47
0
8
0
0
0
0
0
8
0
8
0
% H
% Ile:
0
8
0
8
0
0
0
0
8
8
0
0
0
0
8
% I
% Lys:
0
0
8
0
8
0
8
0
8
8
0
0
0
8
8
% K
% Leu:
0
24
8
0
0
0
8
8
0
0
0
0
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
8
0
8
0
0
0
39
% M
% Asn:
0
0
0
8
0
8
0
8
8
8
8
0
8
0
0
% N
% Pro:
8
8
39
16
8
8
0
8
0
0
8
0
16
54
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
8
8
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
16
54
8
8
8
8
24
62
0
16
16
62
39
0
16
% S
% Thr:
8
0
16
8
47
0
0
0
0
24
54
8
8
0
0
% T
% Val:
8
0
0
0
8
0
39
0
0
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
47
0
8
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _