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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
6.06
Human Site:
S2107
Identified Species:
11.11
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S2107
G
K
K
S
R
R
P
S
A
K
S
T
M
P
T
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
P1821
P
S
A
K
S
T
M
P
T
S
L
P
N
L
A
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S2107
G
K
K
S
R
R
P
S
A
K
N
T
M
P
T
Dog
Lupus familis
XP_540266
2471
265327
N2107
G
K
K
P
R
R
P
N
T
K
S
T
M
P
T
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
N2105
G
K
K
A
R
R
P
N
T
K
S
T
M
P
T
Rat
Rattus norvegicus
Q9QW30
2471
265351
N2107
G
K
K
A
R
R
P
N
T
K
S
T
M
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
P2103
M
G
K
K
P
R
R
P
S
A
K
G
A
V
P
Chicken
Gallus gallus
XP_001233596
2467
266140
N2107
G
P
N
R
S
F
L
N
L
K
H
A
S
L
S
Frog
Xenopus laevis
P21783
2524
275106
K2152
M
K
P
S
V
Q
S
K
K
A
R
K
P
S
I
Zebra Danio
Brachydanio rerio
P46530
2437
262289
A2078
H
L
A
N
R
D
I
A
D
H
L
D
Q
L
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
T2172
P
Q
L
I
T
Q
P
T
V
I
S
A
G
N
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
D1071
S
S
A
E
K
S
E
D
L
I
V
H
E
A
K
Sea Urchin
Strong. purpuratus
P10079
1064
112055
Q706
G
Y
T
A
V
R
C
Q
I
N
I
D
E
C
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
0
93.3
80
N.A.
80
80
N.A.
13.3
13.3
13.3
6.6
N.A.
13.3
N.A.
0
13.3
P-Site Similarity:
100
0
100
86.6
N.A.
93.3
93.3
N.A.
20
26.6
20
20
N.A.
33.3
N.A.
6.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
24
24
0
0
0
8
16
16
0
16
8
8
16
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
0
0
8
0
8
8
0
0
16
0
0
0
% D
% Glu:
0
0
0
8
0
0
8
0
0
0
0
0
16
0
0
% E
% Phe:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% F
% Gly:
54
8
0
0
0
0
0
0
0
0
0
8
8
0
8
% G
% His:
8
0
0
0
0
0
0
0
0
8
8
8
0
0
0
% H
% Ile:
0
0
0
8
0
0
8
0
8
16
8
0
0
0
8
% I
% Lys:
0
47
47
16
8
0
0
8
8
47
8
8
0
0
8
% K
% Leu:
0
8
8
0
0
0
8
0
16
0
16
0
0
24
0
% L
% Met:
16
0
0
0
0
0
8
0
0
0
0
0
39
0
0
% M
% Asn:
0
0
8
8
0
0
0
31
0
8
8
0
8
8
0
% N
% Pro:
16
8
8
8
8
0
47
16
0
0
0
8
8
39
16
% P
% Gln:
0
8
0
0
0
16
0
8
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
8
47
54
8
0
0
0
8
0
0
0
0
% R
% Ser:
8
16
0
24
16
8
8
16
8
8
39
0
8
8
8
% S
% Thr:
0
0
8
0
8
8
0
8
31
0
0
39
0
0
39
% T
% Val:
0
0
0
0
16
0
0
0
8
0
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _