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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
8.79
Human Site:
S1778
Identified Species:
16.11
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S1778
A
E
D
E
A
L
L
S
E
E
D
D
P
I
D
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
N1565
D
A
E
D
S
S
A
N
I
I
T
D
L
V
Y
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S1778
A
E
D
E
A
L
L
S
E
E
D
D
P
I
D
Dog
Lupus familis
XP_540266
2471
265327
S1778
A
E
D
E
A
L
L
S
E
E
D
D
A
I
D
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
L1776
K
A
E
D
E
A
L
L
S
E
D
D
P
I
D
Rat
Rattus norvegicus
Q9QW30
2471
265351
L1778
A
E
D
D
E
A
L
L
S
E
D
D
P
V
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
P1774
T
E
D
Q
A
L
L
P
E
D
T
D
P
V
D
Chicken
Gallus gallus
XP_001233596
2467
266140
P1789
T
E
D
Q
A
L
L
P
E
A
D
E
Q
I
D
Frog
Xenopus laevis
P21783
2524
275106
E1828
E
E
Q
V
I
L
P
E
L
V
D
D
K
T
D
Zebra Danio
Brachydanio rerio
P46530
2437
262289
L1819
R
F
E
G
Q
S
I
L
E
M
S
G
Q
L
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
V1857
Y
A
S
D
H
T
M
V
S
E
Y
E
E
A
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
K815
E
S
E
M
D
R
V
K
M
N
E
R
Q
L
T
Sea Urchin
Strong. purpuratus
P10079
1064
112055
P450
I
D
E
C
A
S
R
P
C
Q
N
G
A
V
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
6.6
100
93.3
N.A.
46.6
60
N.A.
60
60
33.3
13.3
N.A.
13.3
N.A.
0
6.6
P-Site Similarity:
100
40
100
93.3
N.A.
60
73.3
N.A.
80
73.3
33.3
33.3
N.A.
33.3
N.A.
26.6
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
31
24
0
0
47
16
8
0
0
8
0
0
16
8
0
% A
% Cys:
0
0
0
8
0
0
0
0
8
0
0
0
0
0
8
% C
% Asp:
8
8
47
31
8
0
0
0
0
8
54
62
0
0
77
% D
% Glu:
16
54
39
24
16
0
0
8
47
47
8
16
8
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
0
16
0
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
8
0
8
0
8
8
0
0
0
39
0
% I
% Lys:
8
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% K
% Leu:
0
0
0
0
0
47
54
24
8
0
0
0
8
16
0
% L
% Met:
0
0
0
8
0
0
8
0
8
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
8
8
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
24
0
0
0
0
39
0
0
% P
% Gln:
0
0
8
16
8
0
0
0
0
8
0
0
24
0
0
% Q
% Arg:
8
0
0
0
0
8
8
0
0
0
0
8
0
0
0
% R
% Ser:
0
8
8
0
8
24
0
24
24
0
8
0
0
0
0
% S
% Thr:
16
0
0
0
0
8
0
0
0
0
16
0
0
8
8
% T
% Val:
0
0
0
8
0
0
8
8
0
8
0
0
0
31
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _