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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NOTCH2
All Species:
22.42
Human Site:
S1745
Identified Species:
41.11
UniProt:
Q04721
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q04721
NP_077719.2
2471
265405
S1745
K
N
L
S
V
Q
V
S
E
A
N
L
I
G
T
Chimpanzee
Pan troglodytes
XP_513697
2179
233874
L1540
G
P
D
G
C
T
P
L
M
L
A
S
L
R
G
Rhesus Macaque
Macaca mulatta
XP_001114248
2471
265649
S1745
K
N
L
S
V
Q
V
S
E
A
N
L
I
G
S
Dog
Lupus familis
XP_540266
2471
265327
S1745
K
N
L
S
V
Q
V
S
E
A
N
L
I
G
S
Cat
Felis silvestris
Mouse
Mus musculus
O35516
2470
265309
S1744
K
N
L
S
V
Q
V
S
E
A
N
L
I
G
S
Rat
Rattus norvegicus
Q9QW30
2471
265351
S1745
K
N
L
S
V
Q
V
S
E
A
N
L
I
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512292
2467
261963
P1741
K
N
L
S
V
P
V
P
E
G
S
L
I
D
S
Chicken
Gallus gallus
XP_001233596
2467
266140
P1756
K
N
L
S
V
Q
I
P
E
G
N
M
A
D
S
Frog
Xenopus laevis
P21783
2524
275106
F1799
K
N
M
T
D
G
S
F
M
D
D
N
Q
N
E
Zebra Danio
Brachydanio rerio
P46530
2437
262289
S1790
G
L
K
P
L
K
N
S
D
S
S
L
M
D
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07207
2703
288835
A1808
R
N
L
N
K
Q
V
A
M
Q
S
Q
G
V
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P14585
1429
157097
T790
I
S
S
A
L
R
V
T
V
R
I
Q
R
D
E
Sea Urchin
Strong. purpuratus
P10079
1064
112055
G425
D
C
V
D
G
V
N
G
Y
V
C
I
C
A
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
88
99
95.3
N.A.
91.7
92.1
N.A.
78.3
75.8
53.6
53.7
N.A.
42.4
N.A.
21.7
23
Protein Similarity:
100
88.1
99.4
97.5
N.A.
95.3
95.7
N.A.
86.5
85.1
68.2
68.7
N.A.
57.2
N.A.
33.9
30.3
P-Site Identity:
100
0
93.3
93.3
N.A.
93.3
93.3
N.A.
60
53.3
13.3
13.3
N.A.
26.6
N.A.
6.6
0
P-Site Similarity:
100
6.6
100
100
N.A.
100
100
N.A.
73.3
73.3
33.3
53.3
N.A.
53.3
N.A.
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
0
39
8
0
8
8
0
% A
% Cys:
0
8
0
0
8
0
0
0
0
0
8
0
8
0
0
% C
% Asp:
8
0
8
8
8
0
0
0
8
8
8
0
0
31
0
% D
% Glu:
0
0
0
0
0
0
0
0
54
0
0
0
0
0
24
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
16
0
0
8
8
8
0
8
0
16
0
0
8
39
16
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
8
0
0
0
8
8
47
0
0
% I
% Lys:
62
0
8
0
8
8
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
62
0
16
0
0
8
0
8
0
54
8
0
0
% L
% Met:
0
0
8
0
0
0
0
0
24
0
0
8
8
0
0
% M
% Asn:
0
70
0
8
0
0
16
0
0
0
47
8
0
8
0
% N
% Pro:
0
8
0
8
0
8
8
16
0
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
0
54
0
0
0
8
0
16
8
0
0
% Q
% Arg:
8
0
0
0
0
8
0
0
0
8
0
0
8
8
0
% R
% Ser:
0
8
8
54
0
0
8
47
0
8
24
8
0
0
47
% S
% Thr:
0
0
0
8
0
8
0
8
0
0
0
0
0
0
8
% T
% Val:
0
0
8
0
54
8
62
0
8
8
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _