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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLL
All Species:
13.64
Human Site:
Y631
Identified Species:
30
UniProt:
Q03164
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03164
NP_005924.2
3969
431764
Y631
H
S
R
S
E
P
Q
Y
F
S
S
A
K
Y
A
Chimpanzee
Pan troglodytes
XP_508792
3969
431708
Y631
H
S
R
S
E
P
Q
Y
F
S
S
A
K
Y
A
Rhesus Macaque
Macaca mulatta
XP_001093874
3983
436106
F646
S
R
S
E
P
Q
Y
F
S
S
A
K
Y
A
K
Dog
Lupus familis
XP_536554
3923
428640
Y592
H
S
R
S
E
P
Q
Y
F
S
S
A
K
Y
A
Cat
Felis silvestris
Mouse
Mus musculus
P55200
3966
429631
Y629
H
S
R
S
E
P
Q
Y
F
S
S
A
K
Y
A
Rat
Rattus norvegicus
NP_001101609
3725
405813
G585
P
G
S
Q
T
E
K
G
R
K
K
D
T
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417896
1716
188201
Frog
Xenopus laevis
Q66J90
1938
216239
Zebra Danio
Brachydanio rerio
NP_001103749
4218
456340
G658
A
V
V
A
R
G
R
G
N
L
I
I
G
R
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P20659
3726
400080
E589
D
N
D
E
A
V
S
E
K
S
A
E
T
E
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001190252
5353
591425
H639
R
N
G
E
E
L
M
H
I
R
G
R
I
D
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
95.8
92.4
N.A.
91.1
85
N.A.
N.A.
33.3
20
46.4
N.A.
20.6
N.A.
N.A.
22.6
Protein Similarity:
100
99.8
96.5
94.3
N.A.
94.2
87.8
N.A.
N.A.
36.5
30.6
59.7
N.A.
36.3
N.A.
N.A.
37.6
P-Site Identity:
100
100
6.6
100
N.A.
100
0
N.A.
N.A.
0
0
0
N.A.
6.6
N.A.
N.A.
6.6
P-Site Similarity:
100
100
20
100
N.A.
100
6.6
N.A.
N.A.
0
0
13.3
N.A.
20
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
10
10
0
0
0
0
0
19
37
0
19
37
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
0
0
0
0
0
0
0
0
10
0
10
0
% D
% Glu:
0
0
0
28
46
10
0
10
0
0
0
10
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
10
37
0
0
0
0
0
0
% F
% Gly:
0
10
10
0
0
10
0
19
0
0
10
0
10
0
10
% G
% His:
37
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
10
10
10
0
0
% I
% Lys:
0
0
0
0
0
0
10
0
10
10
10
10
37
0
28
% K
% Leu:
0
0
0
0
0
10
0
0
0
10
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% M
% Asn:
0
19
0
0
0
0
0
0
10
0
0
0
0
0
0
% N
% Pro:
10
0
0
0
10
37
0
0
0
0
0
0
0
0
10
% P
% Gln:
0
0
0
10
0
10
37
0
0
0
0
0
0
0
0
% Q
% Arg:
10
10
37
0
10
0
10
0
10
10
0
10
0
10
0
% R
% Ser:
10
37
19
37
0
0
10
0
10
55
37
0
0
0
0
% S
% Thr:
0
0
0
0
10
0
0
0
0
0
0
0
19
0
0
% T
% Val:
0
10
10
0
0
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
10
37
0
0
0
0
10
37
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _