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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLL All Species: 30.3
Human Site: Y1576 Identified Species: 66.67
UniProt: Q03164 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q03164 NP_005924.2 3969 431764 Y1576 C P L C D K C Y D D D D Y E S
Chimpanzee Pan troglodytes XP_508792 3969 431708 Y1576 C P L C D K C Y D D D D Y E S
Rhesus Macaque Macaca mulatta XP_001093874 3983 436106 Y1590 C P L C D K C Y D D D D Y E S
Dog Lupus familis XP_536554 3923 428640 Y1537 C P L C D K C Y D D D D Y E S
Cat Felis silvestris
Mouse Mus musculus P55200 3966 429631 Y1575 C P L C D K C Y D D D D Y E S
Rat Rattus norvegicus NP_001101609 3725 405813 Q1425 S H L L R Y R Q A A K P P D L
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_417896 1716 188201
Frog Xenopus laevis Q66J90 1938 216239
Zebra Danio Brachydanio rerio NP_001103749 4218 456340 Y1770 C P L C N K G Y D D D D C D S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P20659 3726 400080 Y1431 C P I C Q R C Y D D N D F D L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001190252 5353 591425 Y1569 C P V C K K C Y E D D D F E S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 95.8 92.4 N.A. 91.1 85 N.A. N.A. 33.3 20 46.4 N.A. 20.6 N.A. N.A. 22.6
Protein Similarity: 100 99.8 96.5 94.3 N.A. 94.2 87.8 N.A. N.A. 36.5 30.6 59.7 N.A. 36.3 N.A. N.A. 37.6
P-Site Identity: 100 100 100 100 N.A. 100 6.6 N.A. N.A. 0 0 73.3 N.A. 53.3 N.A. N.A. 73.3
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. N.A. 0 0 86.6 N.A. 86.6 N.A. N.A. 93.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 10 10 0 0 0 0 0 % A
% Cys: 73 0 0 73 0 0 64 0 0 0 0 0 10 0 0 % C
% Asp: 0 0 0 0 46 0 0 0 64 73 64 73 0 28 0 % D
% Glu: 0 0 0 0 0 0 0 0 10 0 0 0 0 55 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 19 0 0 % F
% Gly: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % G
% His: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 10 64 0 0 0 0 10 0 0 0 0 % K
% Leu: 0 0 64 10 0 0 0 0 0 0 0 0 0 0 19 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % N
% Pro: 0 73 0 0 0 0 0 0 0 0 0 10 10 0 0 % P
% Gln: 0 0 0 0 10 0 0 10 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 10 10 10 0 0 0 0 0 0 0 0 % R
% Ser: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 64 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 10 0 73 0 0 0 0 46 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _