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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLL
All Species:
13.64
Human Site:
T616
Identified Species:
30
UniProt:
Q03164
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03164
NP_005924.2
3969
431764
T616
K
S
I
L
R
E
P
T
F
R
W
T
S
L
K
Chimpanzee
Pan troglodytes
XP_508792
3969
431708
T616
K
S
I
L
R
E
P
T
F
R
W
T
S
L
K
Rhesus Macaque
Macaca mulatta
XP_001093874
3983
436106
F631
S
I
L
R
E
P
T
F
R
W
T
S
L
K
H
Dog
Lupus familis
XP_536554
3923
428640
T577
K
S
I
L
R
E
P
T
F
R
W
T
S
L
K
Cat
Felis silvestris
Mouse
Mus musculus
P55200
3966
429631
T614
K
S
I
L
R
E
P
T
F
R
W
T
S
L
K
Rat
Rattus norvegicus
NP_001101609
3725
405813
P570
E
P
F
S
S
N
S
P
A
L
F
P
W
F
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417896
1716
188201
Frog
Xenopus laevis
Q66J90
1938
216239
Zebra Danio
Brachydanio rerio
NP_001103749
4218
456340
R643
E
H
S
R
R
G
R
R
G
Q
S
H
R
R
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P20659
3726
400080
E574
D
D
D
D
E
E
A
E
E
D
D
E
N
E
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001190252
5353
591425
P624
S
A
A
L
R
T
S
P
L
V
L
F
Q
T
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
95.8
92.4
N.A.
91.1
85
N.A.
N.A.
33.3
20
46.4
N.A.
20.6
N.A.
N.A.
22.6
Protein Similarity:
100
99.8
96.5
94.3
N.A.
94.2
87.8
N.A.
N.A.
36.5
30.6
59.7
N.A.
36.3
N.A.
N.A.
37.6
P-Site Identity:
100
100
0
100
N.A.
100
0
N.A.
N.A.
0
0
6.6
N.A.
6.6
N.A.
N.A.
13.3
P-Site Similarity:
100
100
13.3
100
N.A.
100
13.3
N.A.
N.A.
0
0
20
N.A.
13.3
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
0
0
10
0
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
10
10
10
0
0
0
0
0
10
10
0
0
0
10
% D
% Glu:
19
0
0
0
19
46
0
10
10
0
0
10
0
10
0
% E
% Phe:
0
0
10
0
0
0
0
10
37
0
10
10
0
10
0
% F
% Gly:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
10
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
10
% H
% Ile:
0
10
37
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
37
0
0
0
0
0
0
0
0
0
0
0
0
10
37
% K
% Leu:
0
0
10
46
0
0
0
0
10
10
10
0
10
37
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
10
0
0
0
10
37
19
0
0
0
10
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
10
0
0
10
0
0
% Q
% Arg:
0
0
0
19
55
0
10
10
10
37
0
0
10
10
0
% R
% Ser:
19
37
10
10
10
0
19
0
0
0
10
10
37
0
0
% S
% Thr:
0
0
0
0
0
10
10
37
0
0
10
37
0
10
10
% T
% Val:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
10
37
0
10
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _