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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLL
All Species:
14.85
Human Site:
S2493
Identified Species:
32.67
UniProt:
Q03164
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03164
NP_005924.2
3969
431764
S2493
K
I
G
D
K
G
L
S
M
P
G
V
P
K
A
Chimpanzee
Pan troglodytes
XP_508792
3969
431708
S2493
K
I
G
D
K
G
L
S
M
P
G
V
P
K
A
Rhesus Macaque
Macaca mulatta
XP_001093874
3983
436106
S2507
K
I
G
D
K
G
L
S
M
P
G
V
P
K
A
Dog
Lupus familis
XP_536554
3923
428640
S2453
K
I
G
D
K
V
L
S
L
P
G
A
P
K
A
Cat
Felis silvestris
Mouse
Mus musculus
P55200
3966
429631
P2491
K
I
G
D
K
V
L
P
L
S
G
V
P
K
G
Rat
Rattus norvegicus
NP_001101609
3725
405813
K2283
S
V
K
V
T
P
L
K
M
E
S
E
N
Q
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417896
1716
188201
T299
S
T
T
F
Q
Q
A
T
K
I
K
K
L
R
T
Frog
Xenopus laevis
Q66J90
1938
216239
L521
I
S
S
S
S
S
Q
L
S
P
I
P
P
Y
S
Zebra Danio
Brachydanio rerio
NP_001103749
4218
456340
R2729
Q
P
K
A
G
S
E
R
S
I
R
P
P
Q
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P20659
3726
400080
S2294
M
S
S
N
E
T
E
S
D
V
S
G
Q
G
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001190252
5353
591425
A3535
D
T
K
D
D
K
S
A
L
P
L
D
V
P
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
95.8
92.4
N.A.
91.1
85
N.A.
N.A.
33.3
20
46.4
N.A.
20.6
N.A.
N.A.
22.6
Protein Similarity:
100
99.8
96.5
94.3
N.A.
94.2
87.8
N.A.
N.A.
36.5
30.6
59.7
N.A.
36.3
N.A.
N.A.
37.6
P-Site Identity:
100
100
100
80
N.A.
66.6
13.3
N.A.
N.A.
0
13.3
6.6
N.A.
6.6
N.A.
N.A.
20
P-Site Similarity:
100
100
100
86.6
N.A.
73.3
33.3
N.A.
N.A.
20
20
20
N.A.
20
N.A.
N.A.
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
10
0
0
10
10
0
0
0
10
0
0
46
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
55
10
0
0
0
10
0
0
10
0
0
0
% D
% Glu:
0
0
0
0
10
0
19
0
0
10
0
10
0
0
0
% E
% Phe:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
46
0
10
28
0
0
0
0
46
10
0
10
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
46
0
0
0
0
0
0
0
19
10
0
0
0
0
% I
% Lys:
46
0
28
0
46
10
0
10
10
0
10
10
0
46
0
% K
% Leu:
0
0
0
0
0
0
55
10
28
0
10
0
10
0
0
% L
% Met:
10
0
0
0
0
0
0
0
37
0
0
0
0
0
10
% M
% Asn:
0
0
0
10
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
0
10
0
0
0
10
0
10
0
55
0
19
64
10
0
% P
% Gln:
10
0
0
0
10
10
10
0
0
0
0
0
10
19
0
% Q
% Arg:
0
0
0
0
0
0
0
10
0
0
10
0
0
10
0
% R
% Ser:
19
19
19
10
10
19
10
46
19
10
19
0
0
0
19
% S
% Thr:
0
19
10
0
10
10
0
10
0
0
0
0
0
0
10
% T
% Val:
0
10
0
10
0
19
0
0
0
10
0
37
10
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _