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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HHEX All Species: 16.97
Human Site: S57 Identified Species: 37.33
UniProt: Q03014 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q03014 NP_002720.1 270 30022 S57 T L P S P N S S F T S L V S P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001090597 270 30002 S57 T L P S P N S S F T S L V S P
Dog Lupus familis XP_850204 270 29974 S58 T L P S P N S S F T S L V S S
Cat Felis silvestris
Mouse Mus musculus P43120 271 29968 S58 T L P S P N S S F T S L V S S
Rat Rattus norvegicus A0JPN1 476 50008 G190 F D P K V K E G N T L R D L T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q05502 277 30195 P60 S L P A P P P P T L P S P N S
Frog Xenopus laevis O13023 272 30558 S57 P T L P S P N S S F T S L V A
Zebra Danio Brachydanio rerio Q9IAV3 228 26030 P23 A P P A H P T P F Y I E D I L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650938 323 34643 S72 A P T P S P S S A T N I Y D L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P56407 147 17231
Sea Urchin Strong. purpuratus XP_781292 310 34523 S96 T P T F P G H S F G P S P Y G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.1 97.7 N.A. 92.6 25.6 N.A. N.A. 75.8 73.5 63.3 N.A. 26 N.A. 24 42.5
Protein Similarity: 100 N.A. 98.1 98.1 N.A. 95.9 34.2 N.A. N.A. 81.5 83.8 70.7 N.A. 40.5 N.A. 35.1 53.5
P-Site Identity: 100 N.A. 100 93.3 N.A. 93.3 13.3 N.A. N.A. 20 6.6 13.3 N.A. 20 N.A. 0 26.6
P-Site Similarity: 100 N.A. 100 93.3 N.A. 93.3 13.3 N.A. N.A. 40 26.6 26.6 N.A. 33.3 N.A. 0 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 0 0 19 0 0 0 0 10 0 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 0 0 0 0 0 0 0 0 19 10 0 % D
% Glu: 0 0 0 0 0 0 10 0 0 0 0 10 0 0 0 % E
% Phe: 10 0 0 10 0 0 0 0 55 10 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 10 0 10 0 10 0 0 0 0 10 % G
% His: 0 0 0 0 10 0 10 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 10 10 0 10 0 % I
% Lys: 0 0 0 10 0 10 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 46 10 0 0 0 0 0 0 10 10 37 10 10 19 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 37 10 0 10 0 10 0 0 10 0 % N
% Pro: 10 28 64 19 55 37 10 19 0 0 19 0 19 0 19 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % R
% Ser: 10 0 0 37 19 0 46 64 10 0 37 28 0 37 28 % S
% Thr: 46 10 19 0 0 0 10 0 10 55 10 0 0 0 10 % T
% Val: 0 0 0 0 10 0 0 0 0 0 0 0 37 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 10 0 0 10 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _