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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HHEX
All Species:
17.27
Human Site:
S237
Identified Species:
38
UniProt:
Q03014
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q03014
NP_002720.1
270
30022
S237
S
L
D
S
S
Q
C
S
P
S
P
A
S
Q
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001090597
270
30002
S237
S
L
D
S
S
Q
C
S
P
S
P
A
S
Q
E
Dog
Lupus familis
XP_850204
270
29974
S237
A
L
D
S
S
Q
C
S
P
S
P
A
S
Q
E
Cat
Felis silvestris
Mouse
Mus musculus
P43120
271
29968
S238
S
L
D
R
S
Q
C
S
P
S
P
A
S
Q
E
Rat
Rattus norvegicus
A0JPN1
476
50008
E373
S
E
G
E
A
E
S
E
S
S
D
S
E
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q05502
277
30195
S243
G
E
A
E
P
Q
D
S
P
S
A
A
S
Q
E
Frog
Xenopus laevis
O13023
272
30558
T238
E
S
S
L
D
D
P
T
S
S
P
T
S
Q
G
Zebra Danio
Brachydanio rerio
Q9IAV3
228
26030
R195
A
E
D
S
D
T
R
R
L
S
D
A
A
A
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650938
323
34643
R291
L
N
L
G
S
G
S
R
C
G
Q
Q
S
D
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P56407
147
17231
K115
D
V
T
E
T
Q
V
K
I
W
F
Q
N
R
R
Sea Urchin
Strong. purpuratus
XP_781292
310
34523
G277
P
L
G
D
N
R
N
G
S
L
T
D
L
E
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.1
97.7
N.A.
92.6
25.6
N.A.
N.A.
75.8
73.5
63.3
N.A.
26
N.A.
24
42.5
Protein Similarity:
100
N.A.
98.1
98.1
N.A.
95.9
34.2
N.A.
N.A.
81.5
83.8
70.7
N.A.
40.5
N.A.
35.1
53.5
P-Site Identity:
100
N.A.
100
93.3
N.A.
93.3
13.3
N.A.
N.A.
53.3
26.6
26.6
N.A.
20
N.A.
6.6
6.6
P-Site Similarity:
100
N.A.
100
100
N.A.
93.3
33.3
N.A.
N.A.
53.3
33.3
40
N.A.
20
N.A.
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
0
10
0
10
0
0
0
0
0
10
55
10
10
0
% A
% Cys:
0
0
0
0
0
0
37
0
10
0
0
0
0
0
0
% C
% Asp:
10
0
46
10
19
10
10
0
0
0
19
10
0
10
10
% D
% Glu:
10
28
0
28
0
10
0
10
0
0
0
0
10
10
55
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% F
% Gly:
10
0
19
10
0
10
0
10
0
10
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% K
% Leu:
10
46
10
10
0
0
0
0
10
10
0
0
10
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
10
0
10
0
0
0
0
0
10
0
0
% N
% Pro:
10
0
0
0
10
0
10
0
46
0
46
0
0
0
0
% P
% Gln:
0
0
0
0
0
55
0
0
0
0
10
19
0
55
0
% Q
% Arg:
0
0
0
10
0
10
10
19
0
0
0
0
0
10
19
% R
% Ser:
37
10
10
37
46
0
19
46
28
73
0
10
64
10
0
% S
% Thr:
0
0
10
0
10
10
0
10
0
0
10
10
0
0
0
% T
% Val:
0
10
0
0
0
0
10
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _