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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
25.43
Human Site:
T7
Identified Species:
43.04
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
T7
_
M
P
K
K
K
P
T
P
I
Q
L
N
P
A
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
T7
_
M
P
K
K
K
P
T
P
I
Q
L
N
P
A
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
T7
_
M
P
K
K
K
P
T
P
I
Q
L
N
P
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
T7
_
M
P
K
K
K
P
T
P
I
Q
L
N
P
A
Rat
Rattus norvegicus
Q01986
393
43447
T7
_
M
P
K
K
K
P
T
P
I
Q
L
N
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
G26
T
H
R
C
D
P
T
G
G
I
R
V
Q
P
A
Chicken
Gallus gallus
Q90891
398
44059
P10
A
K
R
K
P
V
L
P
A
L
T
I
T
P
S
Frog
Xenopus laevis
Q05116
395
43724
T7
_
M
P
K
K
K
P
T
P
I
Q
L
N
P
N
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
K10
G
G
S
D
K
E
S
K
V
F
C
D
S
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
T15
L
V
L
P
P
V
N
T
E
A
T
V
A
A
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
L10
S
G
K
R
R
N
P
L
G
L
S
L
P
P
T
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
S23
I
M
P
I
Q
S
E
S
N
G
G
G
Q
K
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
L10
K
G
G
F
S
N
N
L
K
L
A
I
P
V
A
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
Q20
K
T
G
K
S
S
I
Q
L
N
E
Q
T
G
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
20
13.3
92.8
13.3
N.A.
13.3
N.A.
20
20
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
33.3
33.3
92.8
40
N.A.
26.6
N.A.
40
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
8
8
8
0
8
8
65
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
0
0
0
8
8
0
0
0
0
0
0
8
0
0
0
% D
% Glu:
0
0
0
0
0
8
8
0
8
0
8
0
0
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
8
22
15
0
0
0
0
8
15
8
8
8
0
8
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
8
0
0
8
0
0
50
0
15
0
0
0
% I
% Lys:
15
8
8
58
50
43
0
8
8
0
0
0
0
8
0
% K
% Leu:
8
0
8
0
0
0
8
15
8
22
0
50
0
0
0
% L
% Met:
0
50
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
15
15
0
8
8
0
0
43
0
8
% N
% Pro:
0
0
50
8
15
8
50
8
43
0
0
0
15
72
0
% P
% Gln:
0
0
0
0
8
0
0
8
0
0
43
8
15
0
0
% Q
% Arg:
0
0
15
8
8
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
8
0
8
0
15
15
8
8
0
0
8
0
8
0
22
% S
% Thr:
8
8
0
0
0
0
8
50
0
0
15
0
15
0
8
% T
% Val:
0
8
0
0
0
15
0
0
8
0
0
15
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
43
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _