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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC10
All Species:
31.21
Human Site:
Y495
Identified Species:
62.42
UniProt:
Q01780
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01780
NP_002676.1
885
100831
Y495
D
E
S
Y
L
E
L
Y
R
K
Q
K
K
H
L
Chimpanzee
Pan troglodytes
XP_514382
885
100746
Y495
D
E
S
Y
L
E
L
Y
R
K
Q
K
K
H
L
Rhesus Macaque
Macaca mulatta
XP_001103014
884
100980
Y495
D
E
S
Y
L
E
L
Y
R
K
Q
K
K
H
L
Dog
Lupus familis
XP_535408
1012
115406
Y621
D
E
S
Y
L
E
L
Y
R
K
Q
K
K
H
L
Cat
Felis silvestris
Mouse
Mus musculus
P56960
887
100953
Y495
D
E
S
Y
L
E
L
Y
R
K
Q
K
K
H
L
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001012748
910
103885
Y513
D
E
S
Y
L
E
L
Y
R
R
Q
K
K
H
L
Frog
Xenopus laevis
NP_001084822
883
101879
Y491
E
E
S
Y
L
D
L
Y
Q
K
Q
K
K
H
L
Zebra Danio
Brachydanio rerio
NP_957383
899
102353
Y493
E
D
S
Y
M
E
L
Y
R
K
Q
K
K
S
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097795
900
102900
V477
P
E
S
H
L
D
L
V
R
K
T
K
R
S
F
Honey Bee
Apis mellifera
XP_396975
722
84430
K379
L
S
L
A
Y
L
L
K
H
Y
C
N
V
D
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198503
819
91757
F471
N
D
S
H
V
T
A
F
Q
K
N
R
K
I
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12149
733
84020
L390
S
N
K
L
A
G
V
L
Y
E
S
R
N
V
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.8
77.9
N.A.
87
N.A.
N.A.
N.A.
70.8
65.1
59.8
N.A.
30.7
34.5
N.A.
38.7
Protein Similarity:
100
99.8
98.6
82.2
N.A.
92.2
N.A.
N.A.
N.A.
82.6
79.8
75.8
N.A.
51.1
53.4
N.A.
56.2
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
93.3
80
66.6
N.A.
46.6
6.6
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
100
100
86.6
N.A.
66.6
6.6
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
9
0
9
0
0
0
0
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% C
% Asp:
50
17
0
0
0
17
0
0
0
0
0
0
0
9
0
% D
% Glu:
17
67
0
0
0
59
0
0
0
9
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
25
% F
% Gly:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
17
0
0
0
0
9
0
0
0
0
59
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% I
% Lys:
0
0
9
0
0
0
0
9
0
75
0
75
75
0
0
% K
% Leu:
9
0
9
9
67
9
84
9
0
0
0
0
0
0
59
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
9
9
0
0
0
0
0
0
0
0
9
9
9
0
0
% N
% Pro:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% P
% Gln:
0
0
0
0
0
0
0
0
17
0
67
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
67
9
0
17
9
0
0
% R
% Ser:
9
9
84
0
0
0
0
0
0
0
9
0
0
17
0
% S
% Thr:
0
0
0
0
0
9
0
0
0
0
9
0
0
0
0
% T
% Val:
0
0
0
0
9
0
9
9
0
0
0
0
9
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
67
9
0
0
67
9
9
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _