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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC10
All Species:
38.48
Human Site:
T441
Identified Species:
76.97
UniProt:
Q01780
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01780
NP_002676.1
885
100831
T441
L
S
Y
A
R
D
D
T
H
Y
L
L
Y
I
Y
Chimpanzee
Pan troglodytes
XP_514382
885
100746
T441
L
S
Y
A
R
D
D
T
H
Y
L
L
Y
I
Y
Rhesus Macaque
Macaca mulatta
XP_001103014
884
100980
T441
L
S
Y
A
R
D
D
T
H
Y
L
L
Y
I
Y
Dog
Lupus familis
XP_535408
1012
115406
T567
L
N
Y
A
R
D
D
T
H
Y
L
L
Y
I
Y
Cat
Felis silvestris
Mouse
Mus musculus
P56960
887
100953
T441
L
S
Y
A
R
D
D
T
H
Y
L
L
Y
I
Y
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001012748
910
103885
T459
I
Q
Y
A
R
D
D
T
H
Y
L
L
Y
I
Y
Frog
Xenopus laevis
NP_001084822
883
101879
T437
L
E
Y
A
R
V
D
T
H
Y
L
L
Y
I
Y
Zebra Danio
Brachydanio rerio
NP_957383
899
102353
T439
L
K
Y
A
Q
A
D
T
H
Y
L
L
Y
V
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097795
900
102900
T424
V
D
Y
A
R
Q
D
T
H
F
L
I
Y
V
Y
Honey Bee
Apis mellifera
XP_396975
722
84430
K334
F
T
K
P
T
I
L
K
V
F
H
G
A
D
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198503
819
91757
T417
L
H
Y
A
R
E
D
T
H
Y
L
L
Y
I
Y
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12149
733
84020
L346
K
T
S
K
K
Y
Q
L
A
D
W
R
I
R
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.8
77.9
N.A.
87
N.A.
N.A.
N.A.
70.8
65.1
59.8
N.A.
30.7
34.5
N.A.
38.7
Protein Similarity:
100
99.8
98.6
82.2
N.A.
92.2
N.A.
N.A.
N.A.
82.6
79.8
75.8
N.A.
51.1
53.4
N.A.
56.2
P-Site Identity:
100
100
100
93.3
N.A.
100
N.A.
N.A.
N.A.
86.6
86.6
73.3
N.A.
60
0
N.A.
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
93.3
86.6
86.6
N.A.
86.6
13.3
N.A.
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
84
0
9
0
0
9
0
0
0
9
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
50
84
0
0
9
0
0
0
9
0
% D
% Glu:
0
9
0
0
0
9
0
0
0
0
0
0
0
0
0
% E
% Phe:
9
0
0
0
0
0
0
0
0
17
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% G
% His:
0
9
0
0
0
0
0
0
84
0
9
0
0
0
0
% H
% Ile:
9
0
0
0
0
9
0
0
0
0
0
9
9
67
0
% I
% Lys:
9
9
9
9
9
0
0
9
0
0
0
0
0
0
0
% K
% Leu:
67
0
0
0
0
0
9
9
0
0
84
75
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
9
% P
% Gln:
0
9
0
0
9
9
9
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
75
0
0
0
0
0
0
9
0
9
0
% R
% Ser:
0
34
9
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
17
0
0
9
0
0
84
0
0
0
0
0
0
0
% T
% Val:
9
0
0
0
0
9
0
0
9
0
0
0
0
17
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% W
% Tyr:
0
0
84
0
0
9
0
0
0
75
0
0
84
0
84
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _