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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EXOSC10
All Species:
13.03
Human Site:
S593
Identified Species:
26.06
UniProt:
Q01780
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01780
NP_002676.1
885
100831
S593
V
A
A
G
V
K
K
S
G
P
L
P
S
A
E
Chimpanzee
Pan troglodytes
XP_514382
885
100746
S593
V
A
A
G
V
K
K
S
G
P
L
P
S
A
E
Rhesus Macaque
Macaca mulatta
XP_001103014
884
100980
S593
V
A
A
G
V
K
K
S
G
P
L
P
I
A
E
Dog
Lupus familis
XP_535408
1012
115406
G720
A
S
G
V
K
K
S
G
P
L
P
G
P
E
R
Cat
Felis silvestris
Mouse
Mus musculus
P56960
887
100953
S593
N
A
A
G
V
R
K
S
G
P
L
P
S
A
E
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001012748
910
103885
E618
R
T
S
L
S
N
P
E
R
L
E
N
T
F
F
Frog
Xenopus laevis
NP_001084822
883
101879
K588
E
V
G
S
A
K
R
K
G
P
M
A
N
P
E
Zebra Danio
Brachydanio rerio
NP_957383
899
102353
R589
A
E
V
V
A
Q
K
R
K
S
M
T
P
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097795
900
102900
A576
E
A
H
S
S
T
Q
A
A
L
P
P
S
T
K
Honey Bee
Apis mellifera
XP_396975
722
84430
K438
N
G
Q
I
N
I
L
K
V
V
Y
D
R
S
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198503
819
91757
C530
D
Q
G
G
I
L
A
C
C
N
P
V
P
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q12149
733
84020
R449
V
R
E
L
Y
Q
W
R
D
L
I
A
R
R
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.8
77.9
N.A.
87
N.A.
N.A.
N.A.
70.8
65.1
59.8
N.A.
30.7
34.5
N.A.
38.7
Protein Similarity:
100
99.8
98.6
82.2
N.A.
92.2
N.A.
N.A.
N.A.
82.6
79.8
75.8
N.A.
51.1
53.4
N.A.
56.2
P-Site Identity:
100
100
93.3
6.6
N.A.
86.6
N.A.
N.A.
N.A.
0
26.6
6.6
N.A.
20
0
N.A.
6.6
P-Site Similarity:
100
100
93.3
13.3
N.A.
93.3
N.A.
N.A.
N.A.
13.3
46.6
20
N.A.
40
6.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
27.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
42
34
0
17
0
9
9
9
0
0
17
0
34
0
% A
% Cys:
0
0
0
0
0
0
0
9
9
0
0
0
0
0
0
% C
% Asp:
9
0
0
0
0
0
0
0
9
0
0
9
0
0
9
% D
% Glu:
17
9
9
0
0
0
0
9
0
0
9
0
0
9
42
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
9
% F
% Gly:
0
9
25
42
0
0
0
9
42
0
0
9
0
0
0
% G
% His:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
9
9
9
0
0
0
0
9
0
9
0
0
% I
% Lys:
0
0
0
0
9
42
42
17
9
0
0
0
0
9
9
% K
% Leu:
0
0
0
17
0
9
9
0
0
34
34
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
0
0
17
0
0
0
0
% M
% Asn:
17
0
0
0
9
9
0
0
0
9
0
9
9
0
0
% N
% Pro:
0
0
0
0
0
0
9
0
9
42
25
42
25
17
0
% P
% Gln:
0
9
9
0
0
17
9
0
0
0
0
0
0
0
0
% Q
% Arg:
9
9
0
0
0
9
9
17
9
0
0
0
17
9
17
% R
% Ser:
0
9
9
17
17
0
9
34
0
9
0
0
34
9
0
% S
% Thr:
0
9
0
0
0
9
0
0
0
0
0
9
9
9
9
% T
% Val:
34
9
9
17
34
0
0
0
9
9
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
0
0
0
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _