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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCB2
All Species:
23.64
Human Site:
Y999
Identified Species:
47.27
UniProt:
Q00722
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00722
NP_004564.2
1185
134024
Y999
L
R
Q
G
E
E
Q
Y
E
C
V
L
K
R
K
Chimpanzee
Pan troglodytes
XP_001141721
1185
134063
Y999
L
R
Q
G
E
E
Q
Y
E
C
V
L
K
R
K
Rhesus Macaque
Macaca mulatta
XP_001095135
1181
134067
Y995
L
R
Q
G
E
E
Q
Y
E
C
V
L
K
R
K
Dog
Lupus familis
XP_544615
1188
134303
Y1002
L
Q
Q
G
E
E
Q
Y
E
C
I
L
K
R
K
Cat
Felis silvestris
Mouse
Mus musculus
A3KGF7
1181
134528
Y995
Q
Q
Q
G
E
E
Q
Y
R
S
V
L
K
R
K
Rat
Rattus norvegicus
O89040
1183
134864
Y997
Q
Q
Q
G
E
E
Q
Y
R
S
V
L
K
R
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513474
1217
138978
Q1015
L
K
D
K
Q
Q
Q
Q
L
L
N
L
R
Q
E
Chicken
Gallus gallus
Q2VRL0
637
72514
R495
K
P
E
F
L
R
N
R
N
S
T
F
N
P
H
Frog
Xenopus laevis
Q32NH8
758
87399
T616
N
P
D
Q
P
Q
G
T
E
G
Y
S
P
V
N
Zebra Danio
Brachydanio rerio
NP_001116245
1244
141781
R1020
Q
K
Q
M
E
Q
F
R
E
E
H
M
Q
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P25455
1318
146373
Y1125
C
R
E
Y
T
S
Q
Y
R
E
L
Q
E
K
Y
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q944C2
578
66234
G436
M
M
N
N
N
L
S
G
E
V
F
N
P
K
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.1
91.5
N.A.
85.9
85.9
N.A.
44.7
21.5
23.9
42.5
N.A.
35.8
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
97.5
94.9
N.A.
90.7
90.8
N.A.
65.3
33.9
35.4
61.1
N.A.
54
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
73.3
73.3
N.A.
20
0
6.6
20
N.A.
20
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
80
80
N.A.
60
6.6
13.3
53.3
N.A.
46.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
31.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% A
% Cys:
9
0
0
0
0
0
0
0
0
34
0
0
0
0
0
% C
% Asp:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
17
0
59
50
0
0
59
17
0
0
9
0
9
% E
% Phe:
0
0
0
9
0
0
9
0
0
0
9
9
0
0
0
% F
% Gly:
0
0
0
50
0
0
9
9
0
9
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
9
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% I
% Lys:
9
17
0
9
0
0
0
0
0
0
0
0
50
25
50
% K
% Leu:
42
0
0
0
9
9
0
0
9
9
9
59
0
0
9
% L
% Met:
9
9
0
9
0
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
9
0
9
9
9
0
9
0
9
0
9
9
9
0
9
% N
% Pro:
0
17
0
0
9
0
0
0
0
0
0
0
17
9
0
% P
% Gln:
25
25
59
9
9
25
67
9
0
0
0
9
9
9
0
% Q
% Arg:
0
34
0
0
0
9
0
17
25
0
0
0
9
50
0
% R
% Ser:
0
0
0
0
0
9
9
0
0
25
0
9
0
0
0
% S
% Thr:
0
0
0
0
9
0
0
9
0
0
9
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
9
42
0
0
9
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
0
59
0
0
9
0
0
0
9
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _