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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCB2
All Species:
34.24
Human Site:
Y552
Identified Species:
68.48
UniProt:
Q00722
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00722
NP_004564.2
1185
134024
Y552
E
M
S
S
L
V
N
Y
I
Q
P
T
K
F
V
Chimpanzee
Pan troglodytes
XP_001141721
1185
134063
Y552
E
M
S
S
L
V
N
Y
I
Q
P
T
K
F
V
Rhesus Macaque
Macaca mulatta
XP_001095135
1181
134067
Y548
E
M
S
S
L
V
N
Y
I
Q
P
T
K
F
I
Dog
Lupus familis
XP_544615
1188
134303
Y552
E
M
S
S
L
V
N
Y
I
Q
P
T
K
F
I
Cat
Felis silvestris
Mouse
Mus musculus
A3KGF7
1181
134528
Y553
E
M
S
S
L
V
N
Y
I
Q
P
T
K
F
I
Rat
Rattus norvegicus
O89040
1183
134864
Y556
E
M
S
S
L
V
N
Y
I
Q
P
T
K
F
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513474
1217
138978
Y546
E
M
S
N
L
V
N
Y
I
Q
P
V
K
F
E
Chicken
Gallus gallus
Q2VRL0
637
72514
V155
F
K
K
E
H
R
T
V
Y
Q
D
M
N
H
P
Frog
Xenopus laevis
Q32NH8
758
87399
P276
F
L
V
Y
L
C
S
P
E
G
S
I
F
N
V
Zebra Danio
Brachydanio rerio
NP_001116245
1244
141781
Y576
E
M
S
T
L
V
N
Y
I
E
P
V
K
F
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P25455
1318
146373
Y605
E
I
S
A
L
V
N
Y
V
Q
P
I
H
F
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q944C2
578
66234
F96
N
L
D
D
F
F
S
F
L
F
S
D
D
L
N
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.1
91.5
N.A.
85.9
85.9
N.A.
44.7
21.5
23.9
42.5
N.A.
35.8
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
97.5
94.9
N.A.
90.7
90.8
N.A.
65.3
33.9
35.4
61.1
N.A.
54
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
80
6.6
13.3
73.3
N.A.
60
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
86.6
6.6
26.6
86.6
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
31.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
9
0
0
0
0
0
0
9
9
9
0
0
% D
% Glu:
75
0
0
9
0
0
0
0
9
9
0
0
0
0
9
% E
% Phe:
17
0
0
0
9
9
0
9
0
9
0
0
9
75
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% G
% His:
0
0
0
0
9
0
0
0
0
0
0
0
9
9
0
% H
% Ile:
0
9
0
0
0
0
0
0
67
0
0
17
0
0
34
% I
% Lys:
0
9
9
0
0
0
0
0
0
0
0
0
67
0
9
% K
% Leu:
0
17
0
0
84
0
0
0
9
0
0
0
0
9
0
% L
% Met:
0
67
0
0
0
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
9
0
0
9
0
0
75
0
0
0
0
0
9
9
9
% N
% Pro:
0
0
0
0
0
0
0
9
0
0
75
0
0
0
9
% P
% Gln:
0
0
0
0
0
0
0
0
0
75
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
75
50
0
0
17
0
0
0
17
0
0
0
9
% S
% Thr:
0
0
0
9
0
0
9
0
0
0
0
50
0
0
0
% T
% Val:
0
0
9
0
0
75
0
9
9
0
0
17
0
0
25
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
0
75
9
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _