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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCB2
All Species:
25.15
Human Site:
T720
Identified Species:
50.3
UniProt:
Q00722
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00722
NP_004564.2
1185
134024
T720
D
P
K
R
R
Y
R
T
K
L
S
P
S
T
N
Chimpanzee
Pan troglodytes
XP_001141721
1185
134063
T720
D
P
K
R
R
Y
R
T
K
L
S
P
S
T
N
Rhesus Macaque
Macaca mulatta
XP_001095135
1181
134067
T716
D
P
K
R
R
Y
R
T
K
L
S
P
S
T
N
Dog
Lupus familis
XP_544615
1188
134303
T720
D
P
K
R
R
Y
R
T
R
L
S
P
S
A
N
Cat
Felis silvestris
Mouse
Mus musculus
A3KGF7
1181
134528
T721
D
P
K
R
R
Y
R
T
K
L
S
P
T
A
N
Rat
Rattus norvegicus
O89040
1183
134864
T724
D
P
K
R
R
Y
R
T
K
L
S
P
T
A
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513474
1217
138978
K714
D
T
R
R
K
A
F
K
T
K
T
S
Q
G
N
Chicken
Gallus gallus
Q2VRL0
637
72514
L312
G
T
I
E
E
T
M
L
R
K
G
R
D
S
H
Frog
Xenopus laevis
Q32NH8
758
87399
K433
L
R
G
K
I
L
L
K
G
K
K
I
G
R
L
Zebra Danio
Brachydanio rerio
NP_001116245
1244
141781
T744
D
T
K
R
K
Y
R
T
K
T
S
N
N
N
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P25455
1318
146373
R773
D
T
V
R
K
K
F
R
T
K
T
V
R
D
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q944C2
578
66234
I253
D
L
K
Y
K
I
V
I
S
T
K
P
P
K
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.1
91.5
N.A.
85.9
85.9
N.A.
44.7
21.5
23.9
42.5
N.A.
35.8
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
97.5
94.9
N.A.
90.7
90.8
N.A.
65.3
33.9
35.4
61.1
N.A.
54
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
86.6
86.6
N.A.
20
0
0
53.3
N.A.
20
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
40
20
6.6
73.3
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
31.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
9
0
0
0
0
0
0
0
25
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
84
0
0
0
0
0
0
0
0
0
0
0
9
9
0
% D
% Glu:
0
0
0
9
9
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
17
0
0
0
0
0
0
0
0
% F
% Gly:
9
0
9
0
0
0
0
0
9
0
9
0
9
9
9
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% H
% Ile:
0
0
9
0
9
9
0
9
0
0
0
9
0
0
0
% I
% Lys:
0
0
67
9
34
9
0
17
50
34
17
0
0
9
0
% K
% Leu:
9
9
0
0
0
9
9
9
0
50
0
0
0
0
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
9
9
9
67
% N
% Pro:
0
50
0
0
0
0
0
0
0
0
0
59
9
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% Q
% Arg:
0
9
9
75
50
0
59
9
17
0
0
9
9
9
0
% R
% Ser:
0
0
0
0
0
0
0
0
9
0
59
9
34
9
9
% S
% Thr:
0
34
0
0
0
9
0
59
17
17
17
0
17
25
0
% T
% Val:
0
0
9
0
0
0
9
0
0
0
0
9
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
59
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _