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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCB2
All Species:
5.76
Human Site:
S484
Identified Species:
11.52
UniProt:
Q00722
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00722
NP_004564.2
1185
134024
S484
T
G
G
E
A
E
G
S
S
P
P
S
A
P
A
Chimpanzee
Pan troglodytes
XP_001141721
1185
134063
S484
T
G
G
E
A
E
G
S
S
P
P
S
A
P
A
Rhesus Macaque
Macaca mulatta
XP_001095135
1181
134067
E480
S
S
K
D
P
G
G
E
A
E
G
S
S
P
R
Dog
Lupus familis
XP_544615
1188
134303
N484
S
G
G
D
A
E
G
N
C
P
P
N
A
S
V
Cat
Felis silvestris
Mouse
Mus musculus
A3KGF7
1181
134528
L485
G
G
V
A
E
G
S
L
P
S
S
V
P
V
E
Rat
Rattus norvegicus
O89040
1183
134864
S488
S
E
G
G
F
P
S
S
V
P
V
E
E
D
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513474
1217
138978
K478
K
S
S
E
G
S
A
K
K
K
L
S
E
Q
A
Chicken
Gallus gallus
Q2VRL0
637
72514
K87
C
A
Y
S
E
N
R
K
N
L
A
D
T
E
L
Frog
Xenopus laevis
Q32NH8
758
87399
V208
A
L
T
Q
R
D
E
V
L
K
I
F
Q
D
F
Zebra Danio
Brachydanio rerio
NP_001116245
1244
141781
L508
S
D
G
D
V
G
Q
L
M
S
N
G
G
E
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P25455
1318
146373
A537
G
T
G
T
G
S
A
A
G
T
A
G
H
A
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q944C2
578
66234
D28
N
R
G
A
P
P
Q
D
V
V
T
A
F
V
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.1
91.5
N.A.
85.9
85.9
N.A.
44.7
21.5
23.9
42.5
N.A.
35.8
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
97.5
94.9
N.A.
90.7
90.8
N.A.
65.3
33.9
35.4
61.1
N.A.
54
N.A.
N.A.
N.A.
P-Site Identity:
100
100
20
53.3
N.A.
6.6
20
N.A.
20
0
0
6.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
46.6
80
N.A.
6.6
26.6
N.A.
20
6.6
13.3
20
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
31.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
9
0
17
25
0
17
9
9
0
17
9
25
9
25
% A
% Cys:
9
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% C
% Asp:
0
9
0
25
0
9
0
9
0
0
0
9
0
17
0
% D
% Glu:
0
9
0
25
17
25
9
9
0
9
0
9
17
17
17
% E
% Phe:
0
0
0
0
9
0
0
0
0
0
0
9
9
0
9
% F
% Gly:
17
34
59
9
17
25
34
0
9
0
9
17
9
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% I
% Lys:
9
0
9
0
0
0
0
17
9
17
0
0
0
0
9
% K
% Leu:
0
9
0
0
0
0
0
17
9
9
9
0
0
0
9
% L
% Met:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% M
% Asn:
9
0
0
0
0
9
0
9
9
0
9
9
0
0
0
% N
% Pro:
0
0
0
0
17
17
0
0
9
34
25
0
9
25
9
% P
% Gln:
0
0
0
9
0
0
17
0
0
0
0
0
9
9
0
% Q
% Arg:
0
9
0
0
9
0
9
0
0
0
0
0
0
0
9
% R
% Ser:
34
17
9
9
0
17
17
25
17
17
9
34
9
9
0
% S
% Thr:
17
9
9
9
0
0
0
0
0
9
9
0
9
0
9
% T
% Val:
0
0
9
0
9
0
0
9
17
9
9
9
0
17
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _