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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCB2
All Species:
21.82
Human Site:
S256
Identified Species:
43.64
UniProt:
Q00722
Number Species:
11
Phosphosite Substitution
Charge Score:
0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00722
NP_004564.2
1185
134024
S256
Q
R
D
S
R
L
N
S
L
L
F
P
P
A
R
Chimpanzee
Pan troglodytes
XP_001141721
1185
134063
S256
Q
R
D
S
R
L
N
S
L
L
F
P
P
A
R
Rhesus Macaque
Macaca mulatta
XP_001095135
1181
134067
S256
Q
R
D
S
R
L
N
S
L
L
F
P
P
A
R
Dog
Lupus familis
XP_544615
1188
134303
S256
Q
R
D
P
R
L
N
S
L
L
F
P
P
A
R
Cat
Felis silvestris
Mouse
Mus musculus
A3KGF7
1181
134528
S256
Q
R
D
P
R
L
N
S
L
L
F
P
P
A
R
Rat
Rattus norvegicus
O89040
1183
134864
S256
Q
R
D
P
R
L
N
S
L
L
F
P
P
A
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513474
1217
138978
E260
Q
R
D
P
R
L
N
E
I
L
Y
P
P
L
K
Chicken
Gallus gallus
Q2VRL0
637
72514
Frog
Xenopus laevis
Q32NH8
758
87399
Zebra Danio
Brachydanio rerio
NP_001116245
1244
141781
E262
Q
R
D
S
R
L
N
E
V
L
Y
P
P
L
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P25455
1318
146373
E262
Q
R
D
P
R
L
N
E
I
L
Y
P
Y
A
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q944C2
578
66234
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.1
91.5
N.A.
85.9
85.9
N.A.
44.7
21.5
23.9
42.5
N.A.
35.8
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
97.5
94.9
N.A.
90.7
90.8
N.A.
65.3
33.9
35.4
61.1
N.A.
54
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
60
0
0
66.6
N.A.
60
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
80
0
0
86.6
N.A.
73.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
31.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
59
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
75
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
25
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
50
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
17
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
17
% K
% Leu:
0
0
0
0
0
75
0
0
50
75
0
0
0
17
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
75
0
0
0
0
0
0
0
9
% N
% Pro:
0
0
0
42
0
0
0
0
0
0
0
75
67
0
0
% P
% Gln:
75
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
75
0
0
75
0
0
0
0
0
0
0
0
0
50
% R
% Ser:
0
0
0
34
0
0
0
50
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
25
0
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _