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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCB2
All Species:
21.52
Human Site:
S1152
Identified Species:
43.03
UniProt:
Q00722
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00722
NP_004564.2
1185
134024
S1152
C
L
R
T
C
F
P
S
E
A
K
D
K
P
E
Chimpanzee
Pan troglodytes
XP_001141721
1185
134063
S1152
C
L
R
T
C
F
P
S
E
A
K
D
K
P
E
Rhesus Macaque
Macaca mulatta
XP_001095135
1181
134067
S1148
C
F
R
T
C
F
P
S
E
T
K
D
K
P
E
Dog
Lupus familis
XP_544615
1188
134303
S1155
C
L
R
G
C
F
P
S
E
A
K
D
M
P
E
Cat
Felis silvestris
Mouse
Mus musculus
A3KGF7
1181
134528
T1148
Y
F
K
D
C
F
P
T
E
A
E
D
K
P
E
Rat
Rattus norvegicus
O89040
1183
134864
T1150
C
F
K
A
C
F
P
T
E
A
E
E
K
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513474
1217
138978
E1175
A
M
K
G
K
I
S
E
D
G
E
Q
I
S
A
Chicken
Gallus gallus
Q2VRL0
637
72514
S621
T
V
P
L
F
S
K
S
G
G
K
L
E
P
A
Frog
Xenopus laevis
Q32NH8
758
87399
L742
T
K
I
P
P
A
S
L
F
V
H
I
R
V
T
Zebra Danio
Brachydanio rerio
NP_001116245
1244
141781
K1183
L
E
S
K
G
S
R
K
D
S
L
M
G
Q
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P25455
1318
146373
V1263
V
S
S
N
G
F
L
V
L
F
H
G
P
H
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q944C2
578
66234
K562
S
V
P
L
Y
D
R
K
G
E
R
L
V
S
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
96.1
91.5
N.A.
85.9
85.9
N.A.
44.7
21.5
23.9
42.5
N.A.
35.8
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
97.5
94.9
N.A.
90.7
90.8
N.A.
65.3
33.9
35.4
61.1
N.A.
54
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
86.6
N.A.
60
60
N.A.
0
20
0
0
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
86.6
N.A.
80
86.6
N.A.
26.6
33.3
6.6
13.3
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
31.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
9
0
9
0
0
0
42
0
0
0
0
17
% A
% Cys:
42
0
0
0
50
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
9
0
9
0
0
17
0
0
42
0
0
0
% D
% Glu:
0
9
0
0
0
0
0
9
50
9
25
9
9
0
50
% E
% Phe:
0
25
0
0
9
59
0
0
9
9
0
0
0
0
0
% F
% Gly:
0
0
0
17
17
0
0
0
17
17
0
9
9
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
17
0
0
9
9
% H
% Ile:
0
0
9
0
0
9
0
0
0
0
0
9
9
0
0
% I
% Lys:
0
9
25
9
9
0
9
17
0
0
42
0
42
0
0
% K
% Leu:
9
25
0
17
0
0
9
9
9
0
9
17
0
0
0
% L
% Met:
0
9
0
0
0
0
0
0
0
0
0
9
9
0
0
% M
% Asn:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
17
9
9
0
50
0
0
0
0
0
9
59
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
9
0
9
0
% Q
% Arg:
0
0
34
0
0
0
17
0
0
0
9
0
9
0
0
% R
% Ser:
9
9
17
0
0
17
17
42
0
9
0
0
0
17
0
% S
% Thr:
17
0
0
25
0
0
0
17
0
9
0
0
0
0
17
% T
% Val:
9
17
0
0
0
0
0
9
0
9
0
0
9
9
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _