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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA4 All Species: 29.7
Human Site: Y345 Identified Species: 59.39
UniProt: P78363 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78363 NP_000341.2 2273 255944 Y345 N W Y E D N N Y K A F L G I D
Chimpanzee Pan troglodytes XP_001152577 2346 264166 Y418 N W Y E D N N Y K A F L G I D
Rhesus Macaque Macaca mulatta XP_001093459 2148 234326 F315 M A Q V N R T F E E L A L L R
Dog Lupus familis XP_538773 2261 253895 Y330 N W Y E D N N Y K A L F G G N
Cat Felis silvestris
Mouse Mus musculus O35600 2310 260191 Y345 N W Y E D N N Y K A F L G I D
Rat Rattus norvegicus Q7TNJ2 2170 237702 I332 W G V L G P Q I F N F M N D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 Y335 N W Y E D N N Y K A L F G G N
Chicken Gallus gallus XP_422330 2276 256293 Y345 N W Y E D N N Y K A F L G I D
Frog Xenopus laevis NP_001089022 2363 267334 Y345 N W Y E D N N Y K V F L G V N
Zebra Danio Brachydanio rerio XP_683123 2330 265308 Y345 N W Y E D N N Y K A F L G I N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 C136 T S A H Y G V C S E V R N C S
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.1 45.2 51 N.A. 87 45.4 N.A. 50.9 71.6 66.6 63.4 N.A. N.A. N.A. 23.7 N.A.
Protein Similarity: 100 96.3 62 67.9 N.A. 92.8 63.5 N.A. 67.7 83.4 79.7 76.8 N.A. N.A. N.A. 42.1 N.A.
P-Site Identity: 100 100 0 73.3 N.A. 100 6.6 N.A. 73.3 100 80 93.3 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 100 26.6 80 N.A. 100 13.3 N.A. 80 100 93.3 100 N.A. N.A. N.A. 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 37.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 0 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 9 0 0 0 0 0 0 59 0 9 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 9 0 0 0 0 0 9 0 % C
% Asp: 0 0 0 0 67 0 0 0 0 0 0 0 0 9 34 % D
% Glu: 0 0 0 67 0 0 0 0 9 17 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 9 9 0 59 17 0 0 0 % F
% Gly: 0 9 0 0 9 9 0 0 0 0 0 0 67 17 0 % G
% His: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 9 0 0 0 0 0 42 0 % I
% Lys: 0 0 0 0 0 0 0 0 67 0 0 0 0 0 0 % K
% Leu: 0 0 0 9 0 0 0 0 0 0 25 50 9 9 0 % L
% Met: 9 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % M
% Asn: 67 0 0 0 9 67 67 0 0 9 0 0 17 0 34 % N
% Pro: 0 0 0 0 0 9 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 9 0 0 0 9 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 9 0 0 0 0 0 9 0 0 9 % R
% Ser: 0 9 0 0 0 0 0 0 9 0 0 0 0 0 17 % S
% Thr: 9 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % T
% Val: 0 0 9 9 0 0 9 0 0 9 9 0 0 9 0 % V
% Trp: 9 67 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 67 0 9 0 0 67 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _