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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ABCA4 All Species: 9.09
Human Site: S2173 Identified Species: 18.18
UniProt: P78363 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78363 NP_000341.2 2273 255944 S2173 I V T M K I K S P K D D L L P
Chimpanzee Pan troglodytes XP_001152577 2346 264166 S2246 I V T M K I K S P K D D L L P
Rhesus Macaque Macaca mulatta XP_001093459 2148 234326 A2030 T L T L R V P A E R S Q P A A
Dog Lupus familis XP_538773 2261 253895 G2147 T I V V R I A G S S P D L K P
Cat Felis silvestris
Mouse Mus musculus O35600 2310 260191 S2172 I V T M K I K S P K D D L L P
Rat Rattus norvegicus Q7TNJ2 2170 237702 P2053 T L T L R V P P D Q P E P A I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516009 2266 254238 G2152 T I V V R I A G S N P D L K P
Chicken Gallus gallus XP_422330 2276 256293 A2166 I V T L K I K A P K T G M P P
Frog Xenopus laevis NP_001089022 2363 267334 A2252 I V T M K V R A S K P G F A P
Zebra Danio Brachydanio rerio XP_683123 2330 265308 A2218 V V T M K I K A A K P G L S P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34358 1704 191394 V1613 E P N Q R D M V V Q L V Q T R
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q84M24 1882 209045 G1791 S E Q L F R D G G I P L P I F
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 96.1 45.2 51 N.A. 87 45.4 N.A. 50.9 71.6 66.6 63.4 N.A. N.A. N.A. 23.7 N.A.
Protein Similarity: 100 96.3 62 67.9 N.A. 92.8 63.5 N.A. 67.7 83.4 79.7 76.8 N.A. N.A. N.A. 42.1 N.A.
P-Site Identity: 100 100 6.6 26.6 N.A. 100 6.6 N.A. 26.6 60 46.6 60 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 100 46.6 46.6 N.A. 100 46.6 N.A. 46.6 80 66.6 73.3 N.A. N.A. N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 21.9 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 37.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 17 34 9 0 0 0 0 25 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 9 9 0 9 0 25 42 0 0 0 % D
% Glu: 9 9 0 0 0 0 0 0 9 0 0 9 0 0 0 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 0 9 0 9 % F
% Gly: 0 0 0 0 0 0 0 25 9 0 0 25 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 42 17 0 0 0 59 0 0 0 9 0 0 0 9 9 % I
% Lys: 0 0 0 0 50 0 42 0 0 50 0 0 0 17 0 % K
% Leu: 0 17 0 34 0 0 0 0 0 0 9 9 50 25 0 % L
% Met: 0 0 0 42 0 0 9 0 0 0 0 0 9 0 0 % M
% Asn: 0 0 9 0 0 0 0 0 0 9 0 0 0 0 0 % N
% Pro: 0 9 0 0 0 0 17 9 34 0 50 0 25 9 67 % P
% Gln: 0 0 9 9 0 0 0 0 0 17 0 9 9 0 0 % Q
% Arg: 0 0 0 0 42 9 9 0 0 9 0 0 0 0 9 % R
% Ser: 9 0 0 0 0 0 0 25 25 9 9 0 0 9 0 % S
% Thr: 34 0 67 0 0 0 0 0 0 0 9 0 0 9 0 % T
% Val: 9 50 17 17 0 25 0 9 9 0 0 9 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _