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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
STXBP1
All Species:
52.73
Human Site:
T346
Identified Species:
82.86
UniProt:
P61764
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61764
NP_001027392.1
594
67569
T346
K
E
L
S
K
Y
S
T
H
L
H
L
A
E
D
Chimpanzee
Pan troglodytes
XP_001152683
595
67000
T347
K
E
L
N
K
Y
S
T
H
L
H
L
A
D
D
Rhesus Macaque
Macaca mulatta
XP_001095617
580
66142
T332
K
E
L
S
K
Y
S
T
H
L
H
L
A
E
D
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q64324
593
66339
T345
K
E
L
N
K
Y
S
T
H
L
H
L
A
D
D
Rat
Rattus norvegicus
P61765
594
67550
T346
K
E
L
S
K
Y
S
T
H
L
H
L
A
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508183
589
67400
T332
K
E
L
S
K
Y
S
T
H
L
H
L
A
E
D
Chicken
Gallus gallus
Q6R748
594
67454
T346
K
E
L
S
K
Y
S
T
H
L
H
L
A
E
D
Frog
Xenopus laevis
NP_001093335
595
67691
T347
K
E
L
S
K
Y
S
T
H
L
H
L
A
E
D
Zebra Danio
Brachydanio rerio
NP_001020353
591
67111
T346
K
E
L
S
K
Y
S
T
H
L
Q
L
A
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07327
597
67832
T355
K
E
L
S
K
Y
S
T
H
L
H
L
A
E
D
Honey Bee
Apis mellifera
XP_396375
585
66573
T343
K
E
L
S
K
Y
A
T
H
L
Q
L
A
E
D
Nematode Worm
Caenorhab. elegans
P34815
673
76715
T427
K
E
L
N
K
F
S
T
H
I
S
L
A
E
E
Sea Urchin
Strong. purpuratus
NP_999834
593
68046
T343
K
E
L
R
K
Y
T
T
Q
L
K
L
A
E
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZ77
662
75299
L380
E
Q
I
D
K
L
S
L
H
V
E
I
A
R
T
Baker's Yeast
Sacchar. cerevisiae
P30619
724
83462
H371
E
R
R
R
L
I
L
H
K
T
L
V
D
E
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
63.8
97.6
N.A.
N.A.
62.7
100
N.A.
93.4
97.9
92.4
86.5
N.A.
63.4
63.9
52.1
60.9
Protein Similarity:
100
81.1
97.6
N.A.
N.A.
80.6
100
N.A.
96.1
99.4
97.9
94.6
N.A.
78
79.6
67.4
77.7
P-Site Identity:
100
86.6
100
N.A.
N.A.
86.6
100
N.A.
100
100
100
93.3
N.A.
100
86.6
66.6
66.6
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
100
100
100
93.3
N.A.
100
93.3
93.3
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.2
42.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
7
0
0
0
0
0
94
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% C
% Asp:
0
0
0
7
0
0
0
0
0
0
0
0
7
14
74
% D
% Glu:
14
87
0
0
0
0
0
0
0
0
7
0
0
80
14
% E
% Phe:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
87
0
60
0
0
0
0
% H
% Ile:
0
0
7
0
0
7
0
0
0
7
0
7
0
0
0
% I
% Lys:
87
0
0
0
94
0
0
0
7
0
7
0
0
0
0
% K
% Leu:
0
0
87
0
7
7
7
7
0
80
7
87
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
7
0
0
0
0
0
0
7
0
14
0
0
0
0
% Q
% Arg:
0
7
7
14
0
0
0
0
0
0
0
0
0
7
0
% R
% Ser:
0
0
0
60
0
0
80
0
0
0
7
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
7
87
0
7
0
0
0
0
7
% T
% Val:
0
0
0
0
0
0
0
0
0
7
0
7
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
80
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _