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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
STXBP1
All Species:
25.45
Human Site:
S460
Identified Species:
40
UniProt:
P61764
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.36
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P61764
NP_001027392.1
594
67569
S460
D
S
T
L
R
R
R
S
K
P
E
R
K
E
R
Chimpanzee
Pan troglodytes
XP_001152683
595
67000
R459
N
P
G
V
R
Q
E
R
A
R
L
E
P
R
E
Rhesus Macaque
Macaca mulatta
XP_001095617
580
66142
S446
D
S
T
L
R
R
R
S
K
P
E
R
K
E
R
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q64324
593
66339
S457
N
S
A
G
S
G
T
S
S
R
L
E
R
R
E
Rat
Rattus norvegicus
P61765
594
67550
S460
D
S
T
L
R
R
R
S
K
P
E
R
K
E
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508183
589
67400
S446
D
S
T
L
R
R
R
S
K
P
E
R
K
E
R
Chicken
Gallus gallus
Q6R748
594
67454
S460
D
S
T
L
R
R
R
S
K
P
E
R
K
E
R
Frog
Xenopus laevis
NP_001093335
595
67691
S461
D
S
S
L
R
R
R
S
K
P
D
R
K
E
R
Zebra Danio
Brachydanio rerio
NP_001020353
591
67111
R457
I
I
T
D
S
T
L
R
R
G
K
R
M
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07327
597
67832
R464
I
N
V
I
A
D
S
R
K
K
Q
Y
S
V
P
Honey Bee
Apis mellifera
XP_396375
585
66573
G452
I
N
I
V
V
D
G
G
N
R
K
K
L
Y
T
Nematode Worm
Caenorhab. elegans
P34815
673
76715
K538
I
V
T
D
T
G
R
K
K
T
W
T
P
T
K
Sea Urchin
Strong. purpuratus
NP_999834
593
68046
S457
Q
I
I
H
N
Q
R
S
R
K
T
K
P
T
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SZ77
662
75299
R501
F
D
V
L
K
T
K
R
A
A
R
R
D
R
V
Baker's Yeast
Sacchar. cerevisiae
P30619
724
83462
F513
N
I
Y
H
T
S
R
F
V
P
A
V
G
N
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
63.8
97.6
N.A.
N.A.
62.7
100
N.A.
93.4
97.9
92.4
86.5
N.A.
63.4
63.9
52.1
60.9
Protein Similarity:
100
81.1
97.6
N.A.
N.A.
80.6
100
N.A.
96.1
99.4
97.9
94.6
N.A.
78
79.6
67.4
77.7
P-Site Identity:
100
6.6
100
N.A.
N.A.
13.3
100
N.A.
100
100
86.6
20
N.A.
6.6
0
20
13.3
P-Site Similarity:
100
26.6
100
N.A.
N.A.
26.6
100
N.A.
100
100
100
40
N.A.
26.6
26.6
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.2
22.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.2
42.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
7
0
0
0
14
7
7
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
40
7
0
14
0
14
0
0
0
0
7
0
7
7
0
% D
% Glu:
0
0
0
0
0
0
7
0
0
0
34
14
0
40
14
% E
% Phe:
7
0
0
0
0
0
0
7
0
0
0
0
0
0
0
% F
% Gly:
0
0
7
7
0
14
7
7
0
7
0
0
7
0
0
% G
% His:
0
0
0
14
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
27
20
14
7
0
0
0
0
0
0
0
0
0
0
7
% I
% Lys:
0
0
0
0
7
0
7
7
54
14
14
14
40
0
7
% K
% Leu:
0
0
0
47
0
0
7
0
0
0
14
0
7
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% M
% Asn:
20
14
0
0
7
0
0
0
7
0
0
0
0
7
0
% N
% Pro:
0
7
0
0
0
0
0
0
0
47
0
0
20
0
14
% P
% Gln:
7
0
0
0
0
14
0
0
0
0
7
0
0
0
0
% Q
% Arg:
0
0
0
0
47
40
60
27
14
20
7
54
7
20
47
% R
% Ser:
0
47
7
0
14
7
7
54
7
0
0
0
7
0
0
% S
% Thr:
0
0
47
0
14
14
7
0
0
7
7
7
0
14
7
% T
% Val:
0
7
14
14
7
0
0
0
7
0
0
7
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
0
0
0
0
7
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _