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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTEN All Species: 15.15
Human Site: Y377 Identified Species: 41.67
UniProt: P60484 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P60484 NP_000305.3 403 47166 Y377 S D N E P D H Y R Y S D T T D
Chimpanzee Pan troglodytes XP_521544 462 52650 L434 A D N D K E Y L V L T L T K N
Rhesus Macaque Macaca mulatta XP_001102446 270 31559 R245 D N E P D H Y R Y S D T T D S
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O08586 403 47134 Y377 S D N E P D H Y R Y S D T T D
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506371 391 45262 Y365 S D N E P D H Y R Y S D T T D
Chicken Gallus gallus
Frog Xenopus laevis Q9PUT6 402 46859 Y376 S D N E P D H Y R Y S D T T D
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_599147 509 58413 S463 D L I K W Q N S E V H I T S D
Honey Bee Apis mellifera NP_001155985 501 56758 D404 Q I G M G G Q D T P S E S S E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001177499 393 45424 P350 K R V E N E K P R R P S G D S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 74.4 67 N.A. N.A. 99.7 N.A. N.A. 77.4 N.A. 88.5 N.A. N.A. 34.1 40.7 N.A. 54
Protein Similarity: 100 74.4 67 N.A. N.A. 100 N.A. N.A. 83.6 N.A. 93.8 N.A. N.A. 50 56.8 N.A. 68.2
P-Site Identity: 100 20 6.6 N.A. N.A. 100 N.A. N.A. 100 N.A. 100 N.A. N.A. 13.3 6.6 N.A. 13.3
P-Site Similarity: 100 60 20 N.A. N.A. 100 N.A. N.A. 100 N.A. 100 N.A. N.A. 33.3 33.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 23 56 0 12 12 45 0 12 0 0 12 45 0 23 56 % D
% Glu: 0 0 12 56 0 23 0 0 12 0 0 12 0 0 12 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 12 0 12 12 0 0 0 0 0 0 12 0 0 % G
% His: 0 0 0 0 0 12 45 0 0 0 12 0 0 0 0 % H
% Ile: 0 12 12 0 0 0 0 0 0 0 0 12 0 0 0 % I
% Lys: 12 0 0 12 12 0 12 0 0 0 0 0 0 12 0 % K
% Leu: 0 12 0 0 0 0 0 12 0 12 0 12 0 0 0 % L
% Met: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 12 56 0 12 0 12 0 0 0 0 0 0 0 12 % N
% Pro: 0 0 0 12 45 0 0 12 0 12 12 0 0 0 0 % P
% Gln: 12 0 0 0 0 12 12 0 0 0 0 0 0 0 0 % Q
% Arg: 0 12 0 0 0 0 0 12 56 12 0 0 0 0 0 % R
% Ser: 45 0 0 0 0 0 0 12 0 12 56 12 12 23 23 % S
% Thr: 0 0 0 0 0 0 0 0 12 0 12 12 78 45 0 % T
% Val: 0 0 12 0 0 0 0 0 12 12 0 0 0 0 0 % V
% Trp: 0 0 0 0 12 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 23 45 12 45 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _