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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTEN
All Species:
4.55
Human Site:
Y225
Identified Species:
12.5
UniProt:
P60484
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60484
NP_000305.3
403
47166
Y225
C
Q
L
K
V
K
I
Y
S
S
N
S
G
P
T
Chimpanzee
Pan troglodytes
XP_521544
462
52650
K281
G
E
V
R
T
R
D
K
K
G
V
T
I
P
S
Rhesus Macaque
Macaca mulatta
XP_001102446
270
31559
P115
F
E
F
P
Q
P
L
P
V
C
G
D
I
K
V
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O08586
403
47134
Y225
C
Q
L
K
V
K
I
Y
S
S
N
S
G
P
T
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506371
391
45262
G225
L
S
C
F
G
Q
A
G
E
R
G
E
K
S
H
Chicken
Gallus gallus
Frog
Xenopus laevis
Q9PUT6
402
46859
F224
Y
Q
L
K
V
K
I
F
T
S
T
A
G
P
K
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_599147
509
58413
E233
V
L
H
D
S
A
T
E
N
A
K
P
D
R
L
Honey Bee
Apis mellifera
NP_001155985
501
56758
F234
S
E
S
K
K
K
I
F
S
S
E
I
V
E
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001177499
393
45424
F218
Y
Q
Q
K
V
K
I
F
S
S
Q
P
Y
E
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.4
67
N.A.
N.A.
99.7
N.A.
N.A.
77.4
N.A.
88.5
N.A.
N.A.
34.1
40.7
N.A.
54
Protein Similarity:
100
74.4
67
N.A.
N.A.
100
N.A.
N.A.
83.6
N.A.
93.8
N.A.
N.A.
50
56.8
N.A.
68.2
P-Site Identity:
100
6.6
0
N.A.
N.A.
100
N.A.
N.A.
0
N.A.
60
N.A.
N.A.
0
33.3
N.A.
46.6
P-Site Similarity:
100
46.6
13.3
N.A.
N.A.
100
N.A.
N.A.
6.6
N.A.
80
N.A.
N.A.
13.3
46.6
N.A.
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
12
12
0
0
12
0
12
0
0
0
% A
% Cys:
23
0
12
0
0
0
0
0
0
12
0
0
0
0
0
% C
% Asp:
0
0
0
12
0
0
12
0
0
0
0
12
12
0
0
% D
% Glu:
0
34
0
0
0
0
0
12
12
0
12
12
0
23
0
% E
% Phe:
12
0
12
12
0
0
0
34
0
0
0
0
0
0
0
% F
% Gly:
12
0
0
0
12
0
0
12
0
12
23
0
34
0
0
% G
% His:
0
0
12
0
0
0
0
0
0
0
0
0
0
0
12
% H
% Ile:
0
0
0
0
0
0
56
0
0
0
0
12
23
0
0
% I
% Lys:
0
0
0
56
12
56
0
12
12
0
12
0
12
12
12
% K
% Leu:
12
12
34
0
0
0
12
0
0
0
0
0
0
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
12
0
23
0
0
0
0
% N
% Pro:
0
0
0
12
0
12
0
12
0
0
0
23
0
45
0
% P
% Gln:
0
45
12
0
12
12
0
0
0
0
12
0
0
0
0
% Q
% Arg:
0
0
0
12
0
12
0
0
0
12
0
0
0
12
0
% R
% Ser:
12
12
12
0
12
0
0
0
45
56
0
23
0
12
12
% S
% Thr:
0
0
0
0
12
0
12
0
12
0
12
12
0
0
23
% T
% Val:
12
0
12
0
45
0
0
0
12
0
12
0
12
0
34
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
23
0
0
0
0
0
0
23
0
0
0
0
12
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _