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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PTEN All Species: 17.27
Human Site: Y16 Identified Species: 47.5
UniProt: P60484 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P60484 NP_000305.3 403 47166 Y16 V S R N K R R Y Q E D G F D L
Chimpanzee Pan troglodytes XP_521544 462 52650 Q55 A A E E K Q A Q S L Q P S G S
Rhesus Macaque Macaca mulatta XP_001102446 270 31559
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O08586 403 47134 Y16 V S R N K R R Y Q E D G F D L
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506371 391 45262 Y16 V S R N K R R Y Q E D G F D L
Chicken Gallus gallus
Frog Xenopus laevis Q9PUT6 402 46859 Y16 V S R N K R R Y Q E D G F D L
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_599147 509 58413 Y23 V S K K R I R Y K E K G Y D L
Honey Bee Apis mellifera NP_001155985 501 56758 F25 V S K R R R R F T E D G F D L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001177499 393 45424 D17 I D K G F D L D L S Y I Y P N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 74.4 67 N.A. N.A. 99.7 N.A. N.A. 77.4 N.A. 88.5 N.A. N.A. 34.1 40.7 N.A. 54
Protein Similarity: 100 74.4 67 N.A. N.A. 100 N.A. N.A. 83.6 N.A. 93.8 N.A. N.A. 50 56.8 N.A. 68.2
P-Site Identity: 100 6.6 0 N.A. N.A. 100 N.A. N.A. 100 N.A. 100 N.A. N.A. 53.3 66.6 N.A. 0
P-Site Similarity: 100 20 0 N.A. N.A. 100 N.A. N.A. 100 N.A. 100 N.A. N.A. 80 86.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 12 0 0 0 0 12 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 12 0 0 0 12 0 12 0 0 56 0 0 67 0 % D
% Glu: 0 0 12 12 0 0 0 0 0 67 0 0 0 0 0 % E
% Phe: 0 0 0 0 12 0 0 12 0 0 0 0 56 0 0 % F
% Gly: 0 0 0 12 0 0 0 0 0 0 0 67 0 12 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 12 0 0 0 0 12 0 0 0 0 0 12 0 0 0 % I
% Lys: 0 0 34 12 56 0 0 0 12 0 12 0 0 0 0 % K
% Leu: 0 0 0 0 0 0 12 0 12 12 0 0 0 0 67 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 45 0 0 0 0 0 0 0 0 0 0 12 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 12 0 12 0 % P
% Gln: 0 0 0 0 0 12 0 12 45 0 12 0 0 0 0 % Q
% Arg: 0 0 45 12 23 56 67 0 0 0 0 0 0 0 0 % R
% Ser: 0 67 0 0 0 0 0 0 12 12 0 0 12 0 12 % S
% Thr: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % T
% Val: 67 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 56 0 0 12 0 23 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _