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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTEN
All Species:
13.64
Human Site:
S370
Identified Species:
37.5
UniProt:
P60484
Number Species:
8
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P60484
NP_000305.3
403
47166
S370
T
S
V
T
P
D
V
S
D
N
E
P
D
H
Y
Chimpanzee
Pan troglodytes
XP_521544
462
52650
A427
S
I
C
S
I
E
R
A
D
N
D
K
E
Y
L
Rhesus Macaque
Macaca mulatta
XP_001102446
270
31559
D238
S
V
T
P
D
V
S
D
N
E
P
D
H
Y
R
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O08586
403
47134
S370
T
S
V
T
P
D
V
S
D
N
E
P
D
H
Y
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506371
391
45262
S358
T
S
V
T
P
D
V
S
D
N
E
P
D
H
Y
Chicken
Gallus gallus
Frog
Xenopus laevis
Q9PUT6
402
46859
S369
T
S
V
T
P
D
V
S
D
N
E
P
D
H
Y
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_599147
509
58413
D456
Q
P
S
I
K
K
T
D
L
I
K
W
Q
N
S
Honey Bee
Apis mellifera
NP_001155985
501
56758
Q397
N
R
T
G
E
G
I
Q
I
G
M
G
G
Q
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001177499
393
45424
K343
F
K
V
I
C
Y
F
K
R
V
E
N
E
K
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.4
67
N.A.
N.A.
99.7
N.A.
N.A.
77.4
N.A.
88.5
N.A.
N.A.
34.1
40.7
N.A.
54
Protein Similarity:
100
74.4
67
N.A.
N.A.
100
N.A.
N.A.
83.6
N.A.
93.8
N.A.
N.A.
50
56.8
N.A.
68.2
P-Site Identity:
100
13.3
0
N.A.
N.A.
100
N.A.
N.A.
100
N.A.
100
N.A.
N.A.
0
0
N.A.
13.3
P-Site Similarity:
100
60
20
N.A.
N.A.
100
N.A.
N.A.
100
N.A.
100
N.A.
N.A.
13.3
6.6
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
12
0
0
0
0
0
0
0
% A
% Cys:
0
0
12
0
12
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
12
45
0
23
56
0
12
12
45
0
12
% D
% Glu:
0
0
0
0
12
12
0
0
0
12
56
0
23
0
0
% E
% Phe:
12
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
12
0
12
0
0
0
12
0
12
12
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
45
0
% H
% Ile:
0
12
0
23
12
0
12
0
12
12
0
0
0
0
0
% I
% Lys:
0
12
0
0
12
12
0
12
0
0
12
12
0
12
0
% K
% Leu:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
12
0
0
0
0
% M
% Asn:
12
0
0
0
0
0
0
0
12
56
0
12
0
12
0
% N
% Pro:
0
12
0
12
45
0
0
0
0
0
12
45
0
0
12
% P
% Gln:
12
0
0
0
0
0
0
12
0
0
0
0
12
12
0
% Q
% Arg:
0
12
0
0
0
0
12
0
12
0
0
0
0
0
12
% R
% Ser:
23
45
12
12
0
0
12
45
0
0
0
0
0
0
12
% S
% Thr:
45
0
23
45
0
0
12
0
0
0
0
0
0
0
0
% T
% Val:
0
12
56
0
0
12
45
0
0
12
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% W
% Tyr:
0
0
0
0
0
12
0
0
0
0
0
0
0
23
45
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _