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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
BACE1
All Species:
13.03
Human Site:
S308
Identified Species:
28.67
UniProt:
P56817
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56817
NP_036236.1
501
55764
S308
V
F
E
A
A
V
K
S
I
K
A
A
S
S
T
Chimpanzee
Pan troglodytes
XP_508778
415
46502
P251
C
W
Q
A
G
T
T
P
W
N
I
F
P
V
I
Rhesus Macaque
Macaca mulatta
P11489
388
41678
G224
L
S
A
D
D
Q
S
G
S
V
V
I
F
G
G
Dog
Lupus familis
XP_546508
429
48175
P265
C
W
Q
A
G
T
T
P
W
N
I
F
P
V
I
Cat
Felis silvestris
Mouse
Mus musculus
P56818
501
55729
S308
V
F
E
A
A
V
K
S
I
K
A
A
S
S
T
Rat
Rattus norvegicus
P56819
501
55788
S308
V
F
E
A
A
V
K
S
I
K
A
A
S
S
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509790
498
54928
S305
V
F
A
A
A
V
K
S
I
K
T
A
S
S
T
Chicken
Gallus gallus
Q05744
398
43280
L233
T
A
Q
P
G
G
E
L
L
L
G
G
T
D
P
Frog
Xenopus laevis
Q805F2
397
42983
D233
E
L
V
F
G
G
F
D
A
S
R
F
S
G
Q
Zebra Danio
Brachydanio rerio
NP_991267
505
55643
A314
V
F
Q
A
A
V
K
A
I
E
A
A
S
S
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001187192
538
59189
A321
V
F
E
A
I
T
N
A
I
K
A
H
T
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
82.6
23.1
83.2
N.A.
96.2
96.2
N.A.
89.4
23.9
20.7
74.2
N.A.
N.A.
N.A.
N.A.
42.1
Protein Similarity:
100
82.6
38.5
84.4
N.A.
97.5
97.5
N.A.
92.8
39.7
39.7
83.5
N.A.
N.A.
N.A.
N.A.
57.2
P-Site Identity:
100
6.6
0
6.6
N.A.
100
100
N.A.
86.6
0
6.6
80
N.A.
N.A.
N.A.
N.A.
46.6
P-Site Similarity:
100
20
6.6
20
N.A.
100
100
N.A.
86.6
26.6
6.6
100
N.A.
N.A.
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
19
73
46
0
0
19
10
0
46
46
0
0
0
% A
% Cys:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
10
10
0
0
10
0
0
0
0
0
10
0
% D
% Glu:
10
0
37
0
0
0
10
0
0
10
0
0
0
0
0
% E
% Phe:
0
55
0
10
0
0
10
0
0
0
0
28
10
0
0
% F
% Gly:
0
0
0
0
37
19
0
10
0
0
10
10
0
19
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
0
10
0
0
0
55
0
19
10
0
0
19
% I
% Lys:
0
0
0
0
0
0
46
0
0
46
0
0
0
0
10
% K
% Leu:
10
10
0
0
0
0
0
10
10
10
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
0
19
0
0
0
0
0
% N
% Pro:
0
0
0
10
0
0
0
19
0
0
0
0
19
0
10
% P
% Gln:
0
0
37
0
0
10
0
0
0
0
0
0
0
0
10
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% R
% Ser:
0
10
0
0
0
0
10
37
10
10
0
0
55
46
0
% S
% Thr:
10
0
0
0
0
28
19
0
0
0
10
0
19
10
46
% T
% Val:
55
0
10
0
0
46
0
0
0
10
10
0
0
19
0
% V
% Trp:
0
19
0
0
0
0
0
0
19
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _