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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
AP1S2
All Species:
25.76
Human Site:
S149
Identified Species:
40.48
UniProt:
P56377
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P56377
NP_003907.3
157
18615
S149
E
E
A
E
T
P
R
S
V
L
E
E
I
G
L
Chimpanzee
Pan troglodytes
XP_001138231
185
21159
N167
V
Q
E
T
S
K
K
N
V
L
K
A
I
E
Q
Rhesus Macaque
Macaca mulatta
XP_001102358
160
19119
H149
E
K
T
E
T
M
Y
H
S
K
S
F
I
G
F
Dog
Lupus familis
XP_854230
349
39164
S341
K
E
A
E
T
P
R
S
V
L
E
E
I
G
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9DB50
160
18911
S152
K
E
A
E
T
P
R
S
V
L
E
E
I
G
L
Rat
Rattus norvegicus
P62744
142
16999
L135
Q
T
K
V
L
K
Q
L
L
M
L
Q
S
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006261
157
18595
S149
E
E
A
K
T
P
R
S
V
L
E
E
I
G
L
Frog
Xenopus laevis
NP_001088344
160
18927
S152
K
E
T
E
T
P
R
S
V
L
E
E
I
G
L
Zebra Danio
Brachydanio rerio
NP_991121
157
18590
S149
E
E
A
E
T
P
R
S
V
L
E
E
I
G
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_651198
157
18555
S149
Q
E
D
E
T
P
Q
S
F
F
D
D
H
G
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_504559
157
18615
G149
Q
E
E
E
T
P
Q
G
F
F
E
D
H
G
L
Sea Urchin
Strong. purpuratus
XP_001203214
158
18892
N150
E
E
L
E
A
T
R
N
A
L
E
E
M
G
F
Poplar Tree
Populus trichocarpa
Maize
Zea mays
O50016
132
15996
L125
E
F
I
L
A
G
E
L
Q
E
T
S
K
R
Q
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P35181
156
18134
D149
M
D
T
M
E
S
N
D
N
L
E
R
V
L
S
Red Bread Mold
Neurospora crassa
Q7SAQ1
143
16937
L136
K
Q
V
V
L
T
R
L
E
H
L
D
K
L
E
Conservation
Percent
Protein Identity:
100
77.3
90.6
44.9
N.A.
98.1
44.5
N.A.
N.A.
99.3
96.8
92.3
N.A.
82.1
N.A.
78.9
81
Protein Similarity:
100
77.8
91.2
44.9
N.A.
98.1
63.6
N.A.
N.A.
100
97.5
98
N.A.
88.5
N.A.
87.2
88.6
P-Site Identity:
100
20
33.3
93.3
N.A.
93.3
0
N.A.
N.A.
93.3
86.6
100
N.A.
46.6
N.A.
46.6
53.3
P-Site Similarity:
100
53.3
40
100
N.A.
100
33.3
N.A.
N.A.
100
93.3
100
N.A.
73.3
N.A.
66.6
66.6
Percent
Protein Identity:
N.A.
41.4
N.A.
N.A.
54.1
48.4
Protein Similarity:
N.A.
60.5
N.A.
N.A.
73.2
66.2
P-Site Identity:
N.A.
6.6
N.A.
N.A.
13.3
6.6
P-Site Similarity:
N.A.
6.6
N.A.
N.A.
26.6
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
34
0
14
0
0
0
7
0
0
7
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
7
0
0
0
0
7
0
0
7
20
0
0
0
% D
% Glu:
40
60
14
60
7
0
7
0
7
7
60
47
0
7
14
% E
% Phe:
0
7
0
0
0
0
0
0
14
14
0
7
0
0
14
% F
% Gly:
0
0
0
0
0
7
0
7
0
0
0
0
0
67
0
% G
% His:
0
0
0
0
0
0
0
7
0
7
0
0
14
0
0
% H
% Ile:
0
0
7
0
0
0
0
0
0
0
0
0
54
0
0
% I
% Lys:
27
7
7
7
0
14
7
0
0
7
7
0
14
0
0
% K
% Leu:
0
0
7
7
14
0
0
20
7
60
14
0
0
20
54
% L
% Met:
7
0
0
7
0
7
0
0
0
7
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
7
14
7
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
54
0
0
0
0
0
0
0
0
0
% P
% Gln:
20
14
0
0
0
0
20
0
7
0
0
7
0
0
14
% Q
% Arg:
0
0
0
0
0
0
54
0
0
0
0
7
0
7
0
% R
% Ser:
0
0
0
0
7
7
0
47
7
0
7
7
7
0
7
% S
% Thr:
0
7
20
7
60
14
0
0
0
0
7
0
0
0
0
% T
% Val:
7
0
7
14
0
0
0
0
47
0
0
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _