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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PRMT2 All Species: 17.58
Human Site: S392 Identified Species: 32.22
UniProt: P55345 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55345 NP_001526.2 433 49042 S392 T G D V V T G S V V L Q R N P
Chimpanzee Pan troglodytes XP_001161092 433 48995 S392 T G D V V T G S V V L Q R N P
Rhesus Macaque Macaca mulatta XP_001096450 433 49207 S392 T G D V V T G S V V L Q R N P
Dog Lupus familis XP_537926 640 71811 S599 S G D V I T G S V V L Q R N P
Cat Felis silvestris
Mouse Mus musculus Q9R144 448 50458 F404 T G D V V H G F C C V T K K S
Rat Rattus norvegicus Q63009 353 40504 I317 G E E I F G T I G M R P N A K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513883 470 53922 S405 T G D V V T G S A V F Q R D P
Chicken Gallus gallus
Frog Xenopus laevis Q68EZ3 340 37897 G304 E Q D T D I T G D I T L S P S
Zebra Danio Brachydanio rerio Q6NWG4 349 39232 L311 K V E G E I S L Y P S E E N S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786231 282 31591 M246 W L K Q S G K M W P S Q A H L
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001142360 403 44948 I367 E L N K D Q I I E G S V T I S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SU94 390 43875 M354 G E T I T G T M S V S P N K K
Baker's Yeast Sacchar. cerevisiae P38074 348 39768 N312 G E L V C S P N E K N N R D L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 97.6 61.5 N.A. 77.4 29.3 N.A. 67 N.A. 30 30.7 N.A. N.A. N.A. N.A. 30.2
Protein Similarity: 100 100 98.8 65.1 N.A. 84.8 48 N.A. 78.3 N.A. 43.4 45 N.A. N.A. N.A. N.A. 42.4
P-Site Identity: 100 100 100 86.6 N.A. 40 0 N.A. 80 N.A. 6.6 6.6 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 100 100 N.A. 53.3 20 N.A. 86.6 N.A. 13.3 20 N.A. N.A. N.A. N.A. 13.3
Percent
Protein Identity: N.A. 30.4 N.A. 31.4 30 N.A.
Protein Similarity: N.A. 49.4 N.A. 50.1 48.5 N.A.
P-Site Identity: N.A. 0 N.A. 6.6 13.3 N.A.
P-Site Similarity: N.A. 6.6 N.A. 13.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 8 0 0 0 8 8 0 % A
% Cys: 0 0 0 0 8 0 0 0 8 8 0 0 0 0 0 % C
% Asp: 0 0 54 0 16 0 0 0 8 0 0 0 0 16 0 % D
% Glu: 16 24 16 0 8 0 0 0 16 0 0 8 8 0 0 % E
% Phe: 0 0 0 0 8 0 0 8 0 0 8 0 0 0 0 % F
% Gly: 24 47 0 8 0 24 47 8 8 8 0 0 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 16 8 16 8 16 0 8 0 0 0 8 0 % I
% Lys: 8 0 8 8 0 0 8 0 0 8 0 0 8 16 16 % K
% Leu: 0 16 8 0 0 0 0 8 0 0 31 8 0 0 16 % L
% Met: 0 0 0 0 0 0 0 16 0 8 0 0 0 0 0 % M
% Asn: 0 0 8 0 0 0 0 8 0 0 8 8 16 39 0 % N
% Pro: 0 0 0 0 0 0 8 0 0 16 0 16 0 8 39 % P
% Gln: 0 8 0 8 0 8 0 0 0 0 0 47 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 8 0 47 0 0 % R
% Ser: 8 0 0 0 8 8 8 39 8 0 31 0 8 0 31 % S
% Thr: 39 0 8 8 8 39 24 0 0 0 8 8 8 0 0 % T
% Val: 0 8 0 54 39 0 0 0 31 47 8 8 0 0 0 % V
% Trp: 8 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _