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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NR1H2
All Species:
20.91
Human Site:
Y123
Identified Species:
38.33
UniProt:
P55055
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55055
NP_009052.3
461
51102
Y123
V
R
G
G
A
R
R
Y
A
C
R
G
G
G
T
Chimpanzee
Pan troglodytes
XP_512838
512
55356
Y123
V
R
G
G
A
R
R
Y
A
C
R
G
G
G
T
Rhesus Macaque
Macaca mulatta
XP_001115995
461
51038
Y123
V
R
G
G
A
R
R
Y
A
C
R
G
G
G
T
Dog
Lupus familis
XP_851316
455
50496
Y121
V
R
G
G
A
R
R
Y
A
C
R
G
G
G
T
Cat
Felis silvestris
Mouse
Mus musculus
Q60644
446
49701
Y114
V
H
G
G
A
G
R
Y
A
C
R
G
S
G
T
Rat
Rattus norvegicus
Q62755
446
49717
Y114
V
H
G
G
A
G
R
Y
A
C
R
G
S
G
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517956
624
68359
C311
I
K
G
A
R
Y
T
C
H
S
G
G
H
C
P
Chicken
Gallus gallus
NP_989873
409
47037
C96
I
K
G
A
Q
Y
V
C
K
N
G
G
K
C
E
Frog
Xenopus laevis
P28699
476
53015
P102
P
S
S
P
S
P
P
P
P
P
R
V
Y
K
P
Zebra Danio
Brachydanio rerio
Q9PTN2
453
50848
D103
G
N
C
T
I
T
K
D
N
R
R
H
C
Q
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34021
878
93835
C300
T
K
S
A
V
Y
C
C
K
F
G
R
A
C
E
Honey Bee
Apis mellifera
NP_001091685
629
66768
C285
T
K
N
A
V
Y
Q
C
K
Y
G
N
N
C
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123279
490
55735
C133
T
K
N
A
K
Y
N
C
T
R
G
G
N
C
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.9
98.6
93.9
N.A.
88
88.9
N.A.
51.5
63.7
24.3
32.3
N.A.
23.2
32.1
N.A.
38.9
Protein Similarity:
100
79.3
98.9
95.6
N.A.
90.8
90.8
N.A.
60
73.2
40.7
53.4
N.A.
33.9
45.9
N.A.
56.5
P-Site Identity:
100
100
100
100
N.A.
80
80
N.A.
13.3
13.3
6.6
6.6
N.A.
0
0
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
80
80
N.A.
26.6
26.6
13.3
13.3
N.A.
6.6
13.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
39
47
0
0
0
47
0
0
0
8
0
8
% A
% Cys:
0
0
8
0
0
0
8
39
0
47
0
0
8
39
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
31
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
8
0
62
47
0
16
0
0
0
0
39
70
31
47
0
% G
% His:
0
16
0
0
0
0
0
0
8
0
0
8
8
0
0
% H
% Ile:
16
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
39
0
0
8
0
8
0
24
0
0
0
8
8
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
16
0
0
0
8
0
8
8
0
8
16
0
0
% N
% Pro:
8
0
0
8
0
8
8
8
8
8
0
0
0
0
16
% P
% Gln:
0
0
0
0
8
0
8
0
0
0
0
0
0
8
0
% Q
% Arg:
0
31
0
0
8
31
47
0
0
16
62
8
0
0
0
% R
% Ser:
0
8
16
0
8
0
0
0
0
8
0
0
16
0
0
% S
% Thr:
24
0
0
8
0
8
8
0
8
0
0
0
0
0
47
% T
% Val:
47
0
0
0
16
0
8
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
39
0
47
0
8
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _