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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NR1H2 All Species: 14.85
Human Site: T49 Identified Species: 27.22
UniProt: P55055 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P55055 NP_009052.3 461 51102 T49 P D P D V P G T D E A S S A C
Chimpanzee Pan troglodytes XP_512838 512 55356 T49 P D P D V P G T D E A S S A C
Rhesus Macaque Macaca mulatta XP_001115995 461 51038 T49 P D P D V P G T D E A G S A C
Dog Lupus familis XP_851316 455 50496 S49 P D P D V P G S D W A R S A C
Cat Felis silvestris
Mouse Mus musculus Q60644 446 49701 E61 L E P E D E P E R K R K K G P
Rat Rattus norvegicus Q62755 446 49717 E61 L E P E D E P E R K R K K G P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001517956 624 68359 S160 P E P F S S S S S S S S S P P
Chicken Gallus gallus NP_989873 409 47037 L44 K H A E N P P L K R K K G P A
Frog Xenopus laevis P28699 476 53015 N46 P P F E V L A N G G F F R S F
Zebra Danio Brachydanio rerio Q9PTN2 453 50848 D46 S T S A T G Q D E F D R N A P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P34021 878 93835 R228 V N S I S S G R D D L S P S S
Honey Bee Apis mellifera NP_001091685 629 66768 G104 A N A N S P V G S P S A A L Q
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_001123279 490 55735 K63 T L P P L S M K E Q S S P Q S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 75.9 98.6 93.9 N.A. 88 88.9 N.A. 51.5 63.7 24.3 32.3 N.A. 23.2 32.1 N.A. 38.9
Protein Similarity: 100 79.3 98.9 95.6 N.A. 90.8 90.8 N.A. 60 73.2 40.7 53.4 N.A. 33.9 45.9 N.A. 56.5
P-Site Identity: 100 100 93.3 80 N.A. 6.6 6.6 N.A. 26.6 6.6 13.3 6.6 N.A. 20 6.6 N.A. 13.3
P-Site Similarity: 100 100 93.3 86.6 N.A. 26.6 26.6 N.A. 46.6 13.3 26.6 20 N.A. 40 40 N.A. 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 16 8 0 0 8 0 0 0 31 8 8 39 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 31 % C
% Asp: 0 31 0 31 16 0 0 8 39 8 8 0 0 0 0 % D
% Glu: 0 24 0 31 0 16 0 16 16 24 0 0 0 0 0 % E
% Phe: 0 0 8 8 0 0 0 0 0 8 8 8 0 0 8 % F
% Gly: 0 0 0 0 0 8 39 8 8 8 0 8 8 16 0 % G
% His: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 8 0 0 0 0 0 0 8 8 16 8 24 16 0 0 % K
% Leu: 16 8 0 0 8 8 0 8 0 0 8 0 0 8 0 % L
% Met: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % M
% Asn: 0 16 0 8 8 0 0 8 0 0 0 0 8 0 0 % N
% Pro: 47 8 62 8 0 47 24 0 0 8 0 0 16 16 31 % P
% Gln: 0 0 0 0 0 0 8 0 0 8 0 0 0 8 8 % Q
% Arg: 0 0 0 0 0 0 0 8 16 8 16 16 8 0 0 % R
% Ser: 8 0 16 0 24 24 8 16 16 8 24 39 39 16 16 % S
% Thr: 8 8 0 0 8 0 0 24 0 0 0 0 0 0 0 % T
% Val: 8 0 0 0 39 0 8 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _