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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NR1H2
All Species:
16.67
Human Site:
S192
Identified Species:
30.56
UniProt:
P55055
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P55055
NP_009052.3
461
51102
S192
V
G
P
Q
G
S
S
S
S
A
S
G
P
G
A
Chimpanzee
Pan troglodytes
XP_512838
512
55356
S193
V
G
P
Q
G
S
S
S
S
A
S
G
P
G
A
Rhesus Macaque
Macaca mulatta
XP_001115995
461
51038
S193
A
G
P
Q
G
S
S
S
S
A
S
G
P
G
A
Dog
Lupus familis
XP_851316
455
50496
S187
P
V
G
P
M
G
S
S
T
A
C
G
P
G
A
Cat
Felis silvestris
Mouse
Mus musculus
Q60644
446
49701
S178
P
P
S
E
P
A
A
S
S
S
G
R
P
A
A
Rat
Rattus norvegicus
Q62755
446
49717
G178
P
P
T
E
P
A
S
G
S
S
A
R
P
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517956
624
68359
E362
K
L
K
R
Q
E
E
E
Q
A
Q
A
A
P
P
Chicken
Gallus gallus
NP_989873
409
47037
D147
K
L
K
K
Q
E
D
D
Q
A
R
T
V
V
V
Frog
Xenopus laevis
P28699
476
53015
S176
K
C
F
Q
V
G
M
S
K
E
A
V
R
N
D
Zebra Danio
Brachydanio rerio
Q9PTN2
453
50848
Q162
R
L
S
D
E
Q
M
Q
I
I
N
S
L
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34021
878
93835
S369
S
Q
H
G
G
N
G
S
L
A
S
G
G
G
Q
Honey Bee
Apis mellifera
NP_001091685
629
66768
I355
G
S
P
G
S
G
G
I
R
S
D
Q
M
G
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001123279
490
55735
E196
D
Q
S
P
Q
Q
S
E
E
E
S
I
P
L
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
75.9
98.6
93.9
N.A.
88
88.9
N.A.
51.5
63.7
24.3
32.3
N.A.
23.2
32.1
N.A.
38.9
Protein Similarity:
100
79.3
98.9
95.6
N.A.
90.8
90.8
N.A.
60
73.2
40.7
53.4
N.A.
33.9
45.9
N.A.
56.5
P-Site Identity:
100
100
93.3
46.6
N.A.
26.6
26.6
N.A.
6.6
6.6
13.3
0
N.A.
40
13.3
N.A.
20
P-Site Similarity:
100
100
93.3
53.3
N.A.
53.3
53.3
N.A.
13.3
13.3
20
6.6
N.A.
46.6
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
16
8
0
0
54
16
8
8
16
47
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% C
% Asp:
8
0
0
8
0
0
8
8
0
0
8
0
0
0
8
% D
% Glu:
0
0
0
16
8
16
8
16
8
16
0
0
0
0
8
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
24
8
16
31
24
16
8
0
0
8
39
8
47
0
% G
% His:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
8
8
0
8
0
0
0
% I
% Lys:
24
0
16
8
0
0
0
0
8
0
0
0
0
0
0
% K
% Leu:
0
24
0
0
0
0
0
0
8
0
0
0
8
8
8
% L
% Met:
0
0
0
0
8
0
16
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
8
0
0
8
0
% N
% Pro:
24
16
31
16
16
0
0
0
0
0
0
0
54
8
8
% P
% Gln:
0
16
0
31
24
16
0
8
16
0
8
8
0
0
8
% Q
% Arg:
8
0
0
8
0
0
0
0
8
0
8
16
8
0
0
% R
% Ser:
8
8
24
0
8
24
47
54
39
24
39
8
0
0
0
% S
% Thr:
0
0
8
0
0
0
0
0
8
0
0
8
0
0
0
% T
% Val:
16
8
0
0
8
0
0
0
0
0
0
8
8
16
16
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _